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Artesunate drug-loaded 2D nano-shuttle landing on RBCs infected with malaria parasites
- Title
- Artesunate drug-loaded 2D nano-shuttle landing on RBCs infected with malaria parasites
- Authors
- Kim, Ji-Yeong; Shin, Hyun-Il; Lee, Sang-Eun; Piao, Huiyan; Rejinold, N. Sanoj; Choi, Goeun; Choy, Jin-Ho
- Ewha Authors
- 김지영
- SCOPUS Author ID
- 김지영
- Issue Date
- 2022
- Journal Title
- BIOMATERIALS SCIENCE
- ISSN
- 2047-4830
2047-4849
- Citation
- BIOMATERIALS SCIENCE vol. 10, no. 20, pp. 5980 - 5988
- Publisher
- ROYAL SOC CHEMISTRY
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Artesunic acid (AS(0)), a derivative of artemisinin, is recommended for the treatment of severe and complicated malaria, but its use is limited because of limitations such as a short half-life, non-specific targeting capability, low bioavailability, etc. To overcome these issues, a novel 2D inorganic delivery shuttle system for an AS(0) drug to target the malarial host, red blood cells (RBCs), is explored by immobilizing AS(0) into 2D metal hydroxides to form AS(-) (artesunate, the deprotonated form of artesunic acid) nanohybrid drugs. Haemolysis assay showed that the AS(-) nanohybrids not only are haemo-compatible but also target RBCs due to the electrostatic interaction and hydrogen bonding between RBCs and AS(-) nanohybrids. As clearly demonstrated by the subsequent parasite lactate dehydrogenase assay, the antimalarial effect of the AS(-) nanohybrids is determined to be 6 times more effective than that of intact AS(0) against malaria. Therefore, the AS(-) nanohybrids with haemo-compatible 2D inorganic carriers could be the promising drug delivery systems for targeting the malarial host, RBCs.
- DOI
- 10.1039/d2bm00879c
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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