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Association between cancer genes and germ layer specificity

Title
Association between cancer genes and germ layer specificity
Authors
Lee H.Lee S.Cho W.J.Shin M.Park L.
Ewha Authors
이화영
SCOPUS Author ID
이화영scopusscopus
Issue Date
2022
Journal Title
Medical Oncology
ISSN
1357-0560JCR Link
Citation
Medical Oncology vol. 39, no. 12
Keywords
Cancer geneCancer organCell-fate pathwayCOSMIC databaseGerm layer
Publisher
Springer
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Cancer signaling pathways defining cell fates are related to differentiation. During the developmental process, three germ layers (endoderm, mesoderm, and ectoderm) are formed during embryonic development that differentiate into organs via the epigenetic regulation of specific genes. To examine the relationship, the specificities of cancer gene mutations that depend on the germ layers are studied. The major organs affected by cancer were determined based on statistics from the National Cancer Information Center of Korea, and were grouped according to their germ layer origins. Then, the gene mutation frequencies were evaluated to identify any bias based on the differentiation group using the Catalogue of Somatic Mutations in Cancer (COSMIC) database. The chi-square test showed that the p-value of 152 of 166 genes was less than 0.05, and 151 genes showed p-values of less than 0.05 even after adjusting for the false discovery rate (FDR). The germ layer-specific genes were evaluated using visualization based on basic statistics, and the results matched the top ranking genes depending on organs in the COSMIC database. The current study confirmed the germ layer specificity of major cancer genes. The germ layer specificity of mutated driver genes is possibly important in cancer treatments because each mutated gene may react differently depending on the germ layer of origin. By understanding the mechanism of gene mutation in the development and progression of cancer in the context of cell-fate pathways, a more effective therapeutic strategy for cancer can be established. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
DOI
10.1007/s12032-022-01823-8
Appears in Collections:
의과대학 > 의학과 > Journal papers
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