Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김선희 | * |
dc.date.accessioned | 2022-08-12T16:32:03Z | - |
dc.date.available | 2022-08-12T16:32:03Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 2052-1553 | * |
dc.identifier.other | OAK-32200 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/262555 | - |
dc.description.abstract | In naturally occurring metalloenzymes, cooperative multimetallic sites activate, cleave, and form dioxygen bonds. Thus, molecular scaffolds providing multimetallic sites are increasingly being exploited to develop cooperative redox catalysts. Herein, we report a multicopper complex based on a peptide antibiotic, daptomycin (dap), which mediates O-O bond formation and activation reactions. In alkaline media, UV-vis and electron paramagnetic resonance (EPR) spectroscopy showed that dap stabilized up to four Cu(ii) ions (Cu-n-dap, n = 1-4) in a square planar Cu-N-4 geometry, with an axially bound H2O or OH ligand. Cooperative rate enhancement was observed for the O-2 activation, H2O2 disproportionation, and O-2 evolution reactions, only in the presence of the multimetallic Cu complex. In situ Raman spectroscopy was used to study the intermediate species involved in the electrochemical O-2 evolution reaction and understand the catalytic mechanism behind the O-O bond formation. The observed Cu-O species related to the Cu2O2 core suggested a possible radical coupling pathway for the O-O bond formation. This study provides a strategy to repurpose natural calcium-binding peptide antibiotics as ligands, to create multimetallic sites for cooperative catalysis. | * |
dc.language | English | * |
dc.publisher | ROYAL SOC CHEMISTRY | * |
dc.title | Repurposing a peptide antibiotic as a catalyst: a multicopper-daptomycin complex as a cooperative O-O bond formation and activation catalyst | * |
dc.type | Article | * |
dc.relation.issue | 18 | * |
dc.relation.volume | 9 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 4741 | * |
dc.relation.lastpage | 4752 | * |
dc.relation.journaltitle | INORGANIC CHEMISTRY FRONTIERS | * |
dc.identifier.doi | 10.1039/d2qi01440h | * |
dc.identifier.wosid | WOS:000830665900001 | * |
dc.identifier.scopusid | 2-s2.0-85135220514 | * |
dc.author.google | Lee, Yen Jea | * |
dc.author.google | Kim, Haesol | * |
dc.author.google | Kim, Yujeong | * |
dc.author.google | Cho, Kang Hee | * |
dc.author.google | Hong, Sugyeong | * |
dc.author.google | Nam, Ki Tae | * |
dc.author.google | Kim, Sun Hee | * |
dc.author.google | Choi, Chang Hyuck | * |
dc.author.google | Seo, Jiwon | * |
dc.contributor.scopusid | 김선희(57205324645;57196230818) | * |
dc.date.modifydate | 20240130093611 | * |