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Potentials of ketogenic diet against chronic kidney diseases: pharmacological insights and therapeutic prospects

Title
Potentials of ketogenic diet against chronic kidney diseases: pharmacological insights and therapeutic prospects
Authors
Kundu S.Hossain K.S.Moni A.Zahan M.S.Rahman M.M.Uddin M.J.
Ewha Authors
Md Jamal Uddin
SCOPUS Author ID
Md Jamal Uddinscopus
Issue Date
2022
Journal Title
Molecular Biology Reports
ISSN
0301-4851JCR Link
Citation
Molecular Biology Reports vol. 49, no. 10, pp. 9749 - 9758
Keywords
CKDKetogenic dietOxidative stressPharmacological insightsTherapeutic promises
Publisher
Springer Science and Business Media B.V.
Indexed
SCIE; SCOPUS scopus
Document Type
Review
Abstract
Background: Chronic kidney disease (CKD) is a worldwide public health concern. Nutritional interventions become a primary concern in managing various diseases, including CKD. Ketogenic diets (KD) are a popular diet and an increasingly used diet for weight loss. Main body: With the increasing cases of CKD, KD has been proposed as a treatment by many scientists. Several studies have shown that KD can slow down the progression rate of renal abnormalities. Also, this diet is regarded as a safe route for managing CKD. CKD is generally associated with increased inflammation, oxidative stress, fibrosis, autophagy dysfunction, and mitochondrial dysfunction, while all of these can be attenuated by KD. The protective effect of KD is mainly mediated through inhibition of ROS, NF-κB, and p62 signaling. Conclusions: It is suggested that KD could be considered a new strategy for managing and treating CKD more carefully. This review explores the potential of KD on CKD and the mechanism involved in KD-mediated kidney protection. © 2022, The Author(s), under exclusive licence to Springer Nature B.V.
DOI
10.1007/s11033-022-07460-8
Appears in Collections:
연구기관 > 약학연구소 > Journal papers
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