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Smart pH-responsive nanomedicines for disease therapy
- Title
- Smart pH-responsive nanomedicines for disease therapy
- Authors
- Shinn J.; Kwon N.; Lee S.A.; Lee Y.
- Ewha Authors
- 이용현
- SCOPUS Author ID
- 이용현
- Issue Date
- 2022
- Journal Title
- Journal of Pharmaceutical Investigation
- ISSN
- 2093-5552
- Citation
- Journal of Pharmaceutical Investigation vol. 52, no. 4, pp. 427 - 441
- Keywords
- Endosomal escape; Nanomedicines; pH-responsiveness; Tumor microenvironment
- Publisher
- Springer
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Review
- Abstract
- Background: Currently nanomedicines are the focus of attention from researchers and clinicians because of the successes of lipid-nanoparticles-based COVID-19 vaccines. Nanoparticles improve existing treatments by providing a number of advantages including protection of cargo molecules from external stresses, delivery of drugs to target tissues, and sustained drug release. To prevent premature release-related side effects, stable drug loading in nanoformulations is required, but the increased stability of the formulation could also lead to a poor drug-release profile at the target sites. Thus, researchers have exploited differences in a range of properties (e.g., enzyme levels, pH, levels of reduced glutathione, and reactive oxygen species) between non-target and target sites for site-specific release of drugs. Among these environmental stimuli, pH gradients have been widely used to design novel, responsive nanoparticles. Area covered: In this review, we assess drug delivery based on pH-responsive nanoparticles at the levels of tissues (tumor microenvironment, pH ~ 6.5) and of intracellular compartments (endosome and lysosome, pH 4.5–6.5). Upon exposure to these pH stimuli, pH-responsive nanoparticles respond with physicochemical changes to their material structure and surface characteristics. These changes include swelling, dissociation, or surface charge switching, in a manner that favors drug release at the target site (the tumor microenvironment region and the cytosol followed by endosomal escape) rather than the surrounding tissues. Expert opinion: Lastly, we consider the challenges involved in the development of pH-responsive nanomedicines. © 2022, The Author(s) under exclusive licence to The Korean Society of Pharmaceutical Sciences and Technology.
- DOI
- 10.1007/s40005-022-00573-z
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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