Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 한후재 | * |
dc.date.accessioned | 2022-08-02T16:30:38Z | - |
dc.date.available | 2022-08-02T16:30:38Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 0022-5347 | * |
dc.identifier.issn | 1527-3792 | * |
dc.identifier.other | OAK-31840 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/261632 | - |
dc.description.abstract | Purpose: We quantified the familial risk of renal cell cancer (RCC) among firstdegree relatives (FDRs) on a population level, and examined interactions between family history and body mass index or blood glucose. Materials and Methods: Using the National Health Insurance database, which covers the entire Korean population, and the National Health Screening Program, we constructed a cohort of 5,524,403 individuals with blood-related FDRs and their lifestyle factors from 2002 to 2018. We calculated familial risk using incidence risk ratios (IRRs) with 95% confidence intervals, which compares the risk of individuals with and without FDR. The combined effect and interaction of a given risk factor and family history of RCC were measured by the relative excess risk due to interaction. Results: Individuals with affected FDRs showed a 2.29-fold (95% CI 1.68-3.13) increased risk of disease. Familial risk adjusted for lifestyle factors showed minimal attenuation (IRR 2.25; 95% CI: 1.65-3.08), suggesting that genetic predisposition is the main contributor in the familial aggregation of RCC. Individuals with both a positive family history and overweight/obesity (IRR 3.71, 95% CI 2.50-4.92) or hyperglycemia (IRR 4.52, 95% CI 2.59-6.45) had a significantly higher risk that exceeded the sum of their individual risks, suggesting an interaction that was statistically significant (relative excess risk due to interaction 95% CI: 0.91, -0.21-2.12; 2.21, 0.28-4.14). Conclusions: Our findings suggest an interaction between genetic and environmental factors, namely obesity and hyperglycemia. Individuals with both factors should be considered a high-risk group and advised to undergo genetic counseling. | * |
dc.language | English | * |
dc.publisher | LIPPINCOTT WILLIAMS & | * |
dc.publisher | WILKINS | * |
dc.subject | carcinoma | * |
dc.subject | renal cell | * |
dc.subject | gene-environment interaction | * |
dc.subject | obesity | * |
dc.subject | hyperglycemia | * |
dc.title | Familial Risk of Renal Cell Cancer and Interaction with Obesity and Hyperglycemia: A Population-Based Study | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 208 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 251 | * |
dc.relation.lastpage | + | * |
dc.relation.journaltitle | JOURNAL OF UROLOGY | * |
dc.identifier.doi | 10.1097/JU.0000000000002506 | * |
dc.identifier.wosid | WOS:000823292100010 | * |
dc.identifier.scopusid | 2-s2.0-85134342294 | * |
dc.author.google | Lee, Sung Won | * |
dc.author.google | Kim, Hyun Jung | * |
dc.author.google | Kazmi, Sayada Zartasha | * |
dc.author.google | Choi, Yoon Jung | * |
dc.author.google | Hong, Gahwi | * |
dc.author.google | Kim, Young Shin | * |
dc.author.google | Swan, Heather | * |
dc.author.google | Cha, Jaewoo | * |
dc.author.google | Kang, Taeuk | * |
dc.author.google | Hann, Hoo Jae | * |
dc.author.google | Ahn, Hyeong Sik | * |
dc.contributor.scopusid | 한후재(8698607500) | * |
dc.date.modifydate | 20231116120038 | * |