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Dominant predictors of early post-transplant outcomes based on the Korean Organ Transplantation Registry (KOTRY)

Title
Dominant predictors of early post-transplant outcomes based on the Korean Organ Transplantation Registry (KOTRY)
Authors
Jeong J.C.Koo T.Y.Ro H.Lee D.R.Lee D.W.Kim J.Chae D.-W.Kim Y.H.Huh K.H.Park J.B.Han S.Choi S.J.N.Lee S.Min S.-I.Ha J.Kim M.S.Ahn C.Yang J.Kong J.M.Kwon O.J.Kim D.G.Jung C.W.Kim J.K.Kim C.-D.Min J.W.Park S.K.Park Y.H.Park J.H.Song S.H.Ban T.H.Shin H.S.Yang C.W.Lee S.Y.Lee S.-H.Lee S.H.Lee Y.H.Lee J.P.Lee J.-H.Jeon J.S.Jun H.Jeong K.Chung K.Y.Ki J.M.Shin S.Oh J.The KOTRY Study Group
Ewha Authors
정구영송승환
SCOPUS Author ID
정구영scopus; 송승환scopus
Issue Date
2022
Journal Title
Scientific Reports
ISSN
2045-2322JCR Link
Citation
Scientific Reports vol. 12, no. 1
Publisher
Nature Research
Indexed
SCIE; SCOPUS scopus
Document Type
Article
Abstract
Data for Asian kidney transplants are very limited. We investigated the relative importance of prognostic markers in Asian kidney transplants by using Korean Organ Transplantation Registry (KOTRY) cohort. Prediction models were developed by data-driven variable selection approach. The relative importance of the selected predictors was measured by dominance analysis. A total of 4854 kidney transplant donor-recipient pairs were analyzed. Overall patient survival rates were 99.8%, 98.8%, and 91.8% at 1, 3, and 5 years, respectively. Death-censored graft survival rates were 98.4%, 97.0%, and 95.8% at 1, 3, and 5 years. Biopsy-proven acute rejection free survival rates were 90.1%, 87.4%, and 87.03% at 1, 3, and 5 years. The top 3 dominant predictors for recipient mortality within 1 year were recipient cardiovascular disease history, deceased donor, and recipient age. The dominant predictors for death-censored graft loss within 1 year were acute rejection, deceased donor, and desensitization. The dominant predictors to acute rejection within 1 year were donor age, HLA mismatched numbers, and desensitization. We presented clinical characteristics of patients enrolled in KOTRY during the last 5 years and investigated dominant predictors for early post-transplant outcomes, which would be useful for clinical decision-making based on quantitative measures. © 2022, The Author(s).
DOI
10.1038/s41598-022-12302-5
Appears in Collections:
의과대학 > 의학과 > Journal papers
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