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Ureaplasma and Prevotella colonization with Lactobacillus abundance during pregnancy facilitates term birth
- Title
- Ureaplasma and Prevotella colonization with Lactobacillus abundance during pregnancy facilitates term birth
- Authors
- Park S.; You Y.-A.; Kim Y.-H.; Kwon E.; Ansari A.Z.; Kim S.M.; Lee G.; Hur Y.M.; Jung Y.J.; Kim K.; Kim Y.J.
- Ewha Authors
- 김영주; 유영아; 박선화
- SCOPUS Author ID
- 김영주
; 유영아
; 박선화![scopus](/images/layout/icon2.png)
- Issue Date
- 2022
- Journal Title
- Scientific Reports
- ISSN
- 2045-2322
- Citation
- Scientific Reports vol. 12, no. 1
- Publisher
- Nature Research
- Indexed
- SCIE; SCOPUS
![scopus](/images/layout/scopus2.gif)
- Document Type
- Article
- Abstract
- Ureaplasma and Prevotella infections are well-known bacteria associated with preterm birth. However, with the development of metagenome sequencing techniques, it has been found that not all Ureaplasma and Prevotella colonizations cause preterm birth. The purpose of this study was to determine the association between Ureaplasma and Prevotella colonization with the induction of preterm birth even in the presence of Lactobacillus. In this matched case–control study, a total of 203 pregnant Korean women were selected and their cervicovaginal fluid samples were collected during mid-pregnancy. The microbiome profiles of the cervicovaginal fluid were analyzed using 16S rRNA gene amplification. Sequencing data were processed using QIIME1.9.1. Statistical analyses were performed using R software, and microbiome analysis was performed using the MicrobiomeAnalyst and Calypso software. A positive correlation between Ureaplasma and other genera was highly related to preterm birth, but interestingly, there was a negative correlation with Lactobacillus and term birth, with the same pattern observed with Prevotella. Ureaplasma and Prevotella colonization with Lactobacillus abundance during pregnancy facilitates term birth, although Ureaplasma and Prevotella are associated with preterm birth. Balanced colonization between Lactobacillus and Ureaplasma and Prevotella is important to prevent preterm birth. © 2022, The Author(s).
- DOI
- 10.1038/s41598-022-13871-1
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
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s41598-022-13871-1.pdf(2.08 MB)
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