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DL-Polyalanine as a PEG-Free Thermogel
- Title
- DL-Polyalanine as a PEG-Free Thermogel
- Authors
- Lee, Hyun Jung; Jeong, Byeongmoon
- Ewha Authors
- 정병문
- SCOPUS Author ID
- 정병문
- Issue Date
- 2022
- Journal Title
- ACS MACRO LETTERS
- ISSN
- 2161-1653
- Citation
- ACS MACRO LETTERS vol. 11, no. 6, pp. 825 - 829
- Publisher
- AMER CHEMICAL SOC
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Thermogelling behavior of aqueous polymer solutions comes from the delicate balance between hydrophilic and hydrophobic moieties of the polymer. Typically, poly(ethylene glycol) (PEG) has been used as a hydrophilic block in most thermogels reported to date. However, recent papers have suggested the potential immunogenicity of PEG-conjugated compounds. Here, we report that aqueous solutions of dl-polyalanine (DL-PA) with a specific molecular weight can exhibit thermogelling behavior. In particular, DL-PA with a molecular weight (M-n) of 6690 Da, DL-PA67, exhibited sol-to-gel transition at the physiologically important temperature range of 30-40 degrees C. H-1 NMR and FTIR data indicated that the mechanism of thermogelation is related to dehydration and conformational changes of DL-PA67 from random coil to beta-sheet structures. Subcutaneous injection of an aqueous DL-PA67 solution into rats confirmed the gel formation and its histocompatibility with mild tissue irritation.
- DOI
- 10.1021/acsmacrolett.2c00267
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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