Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤주영 | * |
dc.date.accessioned | 2022-06-02T16:32:26Z | - |
dc.date.available | 2022-06-02T16:32:26Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 1433-7851 | * |
dc.identifier.other | OAK-31542 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/261382 | - |
dc.description.abstract | An effective strategy to engineer selective photodynamic agents to surmount bacterial-infected diseases, especially Gram-positive bacteria remains a great challenge. Herein, we developed two examples of compounds for a proof-of-concept study where reactive differences in reactive oxygen species (ROS) can induce selective ablation of Gram-positive bacteria. Sulfur-replaced phenoxazinium (NBS-N) mainly generates a superoxide anion radical capable of selectively killing Gram-positive bacteria, while selenium-substituted phenoxazinium (NBSe-N) has a higher generation of singlet oxygen that can kill both Gram-positive and Gram-negative bacteria. This difference was further evidenced by bacterial fluorescence imaging and morphological changes. Moreover, NBS-N can also successfully heal the Gram-positive bacteria-infected wounds in mice. We believe that such reactive differences may pave a general way to design selective photodynamic agents for ablating Gram-positive bacteria-infected diseases. © 2022 Wiley-VCH GmbH. | * |
dc.language | English | * |
dc.publisher | John Wiley and Sons Inc | * |
dc.subject | Antibacterial Agents | * |
dc.subject | Gram-Positive Bacteria | * |
dc.subject | Photodynamic Therapy | * |
dc.subject | Reactivity Difference | * |
dc.subject | Selective Ablation | * |
dc.title | Reactivity Differences Enable ROS for Selective Ablation of Bacteria | * |
dc.type | Article | * |
dc.relation.issue | 17 | * |
dc.relation.volume | 61 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Angewandte Chemie - International Edition | * |
dc.identifier.doi | 10.1002/anie.202200808 | * |
dc.identifier.scopusid | 2-s2.0-85125367985 | * |
dc.author.google | Wu X. | * |
dc.author.google | Yang M. | * |
dc.author.google | Kim J.S. | * |
dc.author.google | Wang R. | * |
dc.author.google | Kim G. | * |
dc.author.google | Ha J. | * |
dc.author.google | Kim H. | * |
dc.author.google | Cho Y. | * |
dc.author.google | Nam K.T. | * |
dc.author.google | Yoon J. | * |
dc.contributor.scopusid | 윤주영(7403587371) | * |
dc.date.modifydate | 20240118162450 | * |