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Association of atrial fibrillation with infectivity and severe complications of COVID-19: A nationwide cohort study

Title
Association of atrial fibrillation with infectivity and severe complications of COVID-19: A nationwide cohort study
Authors
Park J.Shin J.I.Kim D.-H.Jeon J.Kim J.Song T.-J.
Ewha Authors
박준범송태진박진김동혁
SCOPUS Author ID
박준범scopus; 송태진scopusscopus; 박진scopusscopus; 김동혁scopusscopusscopusscopus
Issue Date
2022
Journal Title
Journal of Medical Virology
ISSN
0146-6615JCR Link
Citation
Journal of Medical Virology vol. 94, no. 6, pp. 2422 - 2430
Keywords
atrial fibrillationCOVID-19infectivityintensive care unitmechanical ventilationmortalityprognosis
Publisher
John Wiley and Sons Inc
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Infection is associated with the occurrence, recurrence, and progression of atrial fibrillation (AF), and is also closely related to poor prognosis. However, studies of the relationship between infectivity and severe complications of coronavirus infectious disease-19 (COVID-19) with a history of AF are limited. To estimate infectivity and severity of complications in COVID-19 patients with a history of AF, this study was done. From the Korean nationwide COVID-19 dataset, 212 678 participants with at least one severe acute respiratory syndrome coronavirus 2 (COVID-19) test were included between January 1 and June 4, 2020. AF was defined according to at least two outpatient hospital visits or one admission with an ICD-10 code of “I48” before the COVID-19 test. To investigate the association of AF with infectivity and severe complications of COVID-19, 1:4 ratio propensity score matching (PSM) was performed. Severe complications of COVID-19 were defined as a composite outcome of mechanical ventilation, intensive care unit admission, and death within 2 months after COVID-19 diagnosis. Among 212 678 participants who underwent the COVID-19 test, there were 7713 COVID-19 positive patients. After PSM, COVID-19 PCR positivity did not show a significant difference according to the presence of AF (odds ratio [OR]: 0.79, 95% confidence interval [CI]: [0.60–1.04]). Of 7713 COVID-19 patients, 62 (0.8%) had a history of AF and severe complications occurred in 444 (5.7%) patients. After PSM, AF was associated with the development of severe complications (OR: 2.04, 95% CI: [1.10–3.79]) and mortality (OR: 2.09, 95% CI: [1.01–4.31]) of COVID-19. We found that AF was associated with an increased risk of severe complications in COVID-19 infected patients. © 2022 Wiley Periodicals LLC.
DOI
10.1002/jmv.27647
Appears in Collections:
의과대학 > 의학과 > Journal papers
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