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Hamuramicin C, a Cytotoxic Bicyclic Macrolide Isolated from a Wasp Gut Bacterium
- Title
- Hamuramicin C, a Cytotoxic Bicyclic Macrolide Isolated from a Wasp Gut Bacterium
- Authors
- An J.S.; Lim H.-J.; Lee J.Y.; Jang Y.-J.; Nam S.-J.; Lee S.K.; Oh D.-C.
- Ewha Authors
- 남상집
- SCOPUS Author ID
- 남상집
- Issue Date
- 2022
- Journal Title
- Journal of Natural Products
- ISSN
- 0163-3864
- Citation
- Journal of Natural Products vol. 85, no. 4, pp. 936 - 942
- Publisher
- American Chemical Society
- Indexed
- SCIE; SCOPUS
- Document Type
- Review
- Abstract
- A new bicyclic macrolide, hamuramicin C (1), was isolated from Streptomyces sp. MBP16, a gut bacterial strain of the wasp Vespa crabro flavofasciata. Its 22-membered macrocyclic lactone structure was determined by NMR and mass spectrometry. The relative configurations of hamuramicin C (1) were assigned by J-based configuration analysis utilizing 1H rotating frame Overhauser effect spectroscopy and heteronuclear long-range coupling NMR spectroscopy. Genomic and bioinformatic analyses of the bacterial strain enabled identification of the type-I polyketide synthase pathway, which employs a trans-acyltransferase system. The absolute configurations of 1 were proposed based on the analysis of the sequences of ketoreductases in the modular gene cluster. Moreover, hamuramicin C (1) demonstrated significant inhibitory activity against diverse human cancer cell lines (HCT116, A549, SNU-638, SK-HEP-1, and MDA-MB-231). © 2022 American Chemical Society. All rights reserved.
- DOI
- 10.1021/acs.jnatprod.1c01075
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
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