Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 송태진 | * |
dc.contributor.author | 김지현 | * |
dc.date.accessioned | 2022-06-02T16:31:02Z | - |
dc.date.available | 2022-06-02T16:31:02Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 0028-3878 | * |
dc.identifier.other | OAK-31476 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/261187 | - |
dc.description.abstract | Background and ObjectivesThe goal of this work was to evaluate whether patients with epilepsy were more susceptible to coronavirus disease 2019 (COVID-19) infection and at greater risk of severe complications when infected with COVID-19 compared with patients without epilepsy.MethodsWe included participants who underwent at least 1 severe acute respiratory syndrome coronavirus 2 real-time reverse-transcription PCR test between January 1 and June 4, 2020, from the Korean nationwide COVID-19 dataset. Epilepsy was defined according to the presence of diagnostic code in health claims data before the COVID-19 diagnosis. To investigate the association between epilepsy and the susceptibility for or severe complications of COVID-19, a 1:6 ratio propensity score matching (PSM) and logistic regression analysis were performed. Severe complications with COVID-19 infection were defined as a composite of the incidence of mechanical ventilation, intensive care unit admission, and death within 2 months after COVID-19 diagnosis.ResultsAmong 212,678 study participants who underwent a COVID-19 test, 3,919 (1.8%) had a history of epilepsy. After PSM, there was no significant difference in COVID-19 PCR positivity according to epilepsy history (odds ratio [OR] 0.86, 95% CI 0.67-1.11). Of the 7,713 individuals with confirmed COVID-19 infection, 72 (0.9%) had a history of epilepsy. Among the patients with COVID-19, severe complications occurred in 444 (5.8%) individuals. After PSM, the presence of epilepsy was associated with the occurrence of severe complications after COVID-19 infection (OR 2.05, 95% CI 1.04-4.04). Mortality after COVID-19 infection did not differ according to the presence of epilepsy history (OR 1.55, 95% CI 0.65-3.70).DiscussionThe presence of epilepsy was not associated with increased susceptibility to COVID-19 infection or mortality related to the infection. However, there was an increased risk of severe complications with COVID-19 in patients with epilepsy; therefore, careful management and monitoring may be necessary. © American Academy of Neurology. Copyright © 2022 American Academy of Neurology. | * |
dc.language | English | * |
dc.publisher | Lippincott Williams and Wilkins | * |
dc.title | Risk of COVID-19 Infection and of Severe Complications Among People With Epilepsy: A Nationwide Cohort Study | * |
dc.type | Article | * |
dc.relation.issue | 19 | * |
dc.relation.volume | 98 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | E1886 | * |
dc.relation.lastpage | E1892 | * |
dc.relation.journaltitle | Neurology | * |
dc.identifier.doi | 10.1212/WNL.0000000000200195 | * |
dc.identifier.wosid | WOS:000794002600014 | * |
dc.identifier.scopusid | 2-s2.0-85130001537 | * |
dc.author.google | Yoo J. | * |
dc.author.google | Kim J.H. | * |
dc.author.google | Jeon J. | * |
dc.author.google | Kim J. | * |
dc.author.google | Song T.-J. | * |
dc.contributor.scopusid | 송태진(55507164200) | * |
dc.contributor.scopusid | 김지현(55932113900) | * |
dc.date.modifydate | 20240315131236 | * |