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The association of plasma osteoprotegerin levels and functional outcomes post endovascular thrombectomy in acute ischemic stroke patients: a retrospective observational study
- Title
- The association of plasma osteoprotegerin levels and functional outcomes post endovascular thrombectomy in acute ischemic stroke patients: a retrospective observational study
- Authors
- Park M.-S.; Park J.-H.; Joo A.; Chang Y.; Song T.-J.
- Ewha Authors
- 송태진; 박진희; 장윤경; 박무석
- SCOPUS Author ID
- 송태진; 박진희; 장윤경; 박무석
- Issue Date
- 2022
- Journal Title
- PeerJ
- ISSN
- 2167-8359
- Citation
- PeerJ vol. 10
- Keywords
- Endovascular thrombectomy; Osteoprotegerin; Prognosis; Stroke
- Publisher
- PeerJ Inc.
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background. Osteoprotegerin (OPG), also known as osteoclastogenesis inhibitory factor, is a tumor necrosis factor receptor superfamily component. There is an established relationship betweenOPGand cardiovascular disease.Wehypothesized that plasma OPG levels are associated with functional outcomes in acute ischemic stroke patients who have undergone endovascular thrombectomy (EVT). Methods. From April 2014 through December 2020, a total of 360 acute ischemic stroke patients who underwent EVT were prospectively included in this retrospective observational study. Plasma OPG was measured after fasting for 12 postoperative hours after EVT. A modified Rankin Scale (mRS) was used to assess functional outcomes 3 months after index stroke occurrence. Univariate and multivariate binary logistic regression and ordinal logistic regression analyses were performed to investigate the association of plasma OPG levels with poor functional outcomes. Results. Overall, 145 (40.2%) patients had poor (mRS > 2) outcomes. The mean ± standard deviation plasma OPG level was 200.2 ± 74.4 pg/mL. Multivariate analysis after adjusting for sex, body mass index, and variables with p < 0:1 in the preceding univariate analysis revealed high plasma OPG levels were independently associated with poor functional outcomes (highest tertile vs. lowest tertile of OPG; odds ratios (OR) 2.121, 95% confidence interval (CI) [1.089-4.191], p = 0:037 in binary logistic regression, OR 2.102, 95% CI [1.301-3.412], p=0:002 in ordinal logistic regression analysis). Conclusions. This study demonstrated that higher plasma OPG levels were associated with poor functional outcomes in acute ischemic stroke patients who underwent EVT. © 2022 Park et al.
- DOI
- 10.7717/peerj.13327
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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