Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 곽혜선 | * |
dc.contributor.author | 송곤진 | * |
dc.contributor.author | 이정 | * |
dc.contributor.author | 김명규 | * |
dc.date.accessioned | 2022-03-31T16:32:31Z | - |
dc.date.available | 2022-03-31T16:32:31Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 0306-5251 | * |
dc.identifier.other | OAK-31200 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/261107 | - |
dc.description.abstract | Aims: Diverse genetic and/or external factors may induce psoriasis. Drug exposure is 1 such prominent external factor; antihypertensive drugs are reportedly associated with psoriasis, but study results have been inconsistent. In this context, we investigated the associations between antihypertensive drugs and incidence if psoriasis via a systematic literature review and meta-analysis. Methods: Literature search in databases such as PubMed, Embase and Web of Science was conducted on 8 January 2021, and obtained data were pooled for meta- and network meta-analysis. Fixed- or random effect models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for evaluating the strength of the associations between antihypertensive drugs and psoriasis incidence. In addition to meta-analysis, Bayesian network meta-analysis was performed. ResultsThirteen eligible studies were included for meta-analysis with 6 378 116 individuals and 8 studies for network meta-analysis with 5 615 918 individuals. All antihypertensive drugs were significantly associated with psoriasis incidence. In a meta-analysis, the pooled ORs were 1.67 (95% CI: 1.31–2.13) for angiotensin-converting enzyme (ACE) inhibitors, 1.40 (95% CI: 1.20–1.63) for β-blockers, 1.53 (95% CI: 1.23–1.89) for calcium-channel blockers (CCBs), and 1.70 (95% CI: 1.40–2.06) for thiazide diuretics. For the comparative risks of psoriasis among antihypertensive drugs in the network meta-analysis, ORs were 2.09 (95% CI: 1.39–3.18) for ACE inhibitors, 1.35 (95% CI: 0.99–1.91) for BBs, 1.53 (95% CI: 1.07–2.24) for CCBs and 1.80 (95% CI: 1.23–2.66) for thiazide diuretics. Conclusion: This study confirmed the associations between antihypertensive drugs and psoriasis; ACE inhibitors, BBs, CCBs and thiazide diuretics increased the risk of psoriasis. Therefore, antihypertensive drug users should be carefully monitored for psoriasis. © 2021 British Pharmacological Society. | * |
dc.language | English | * |
dc.publisher | John Wiley and Sons Inc | * |
dc.subject | adverse events | * |
dc.subject | antihypertensive drugs | * |
dc.subject | meta-analysis | * |
dc.subject | network meta-analysis | * |
dc.subject | psoriasis | * |
dc.subject | systematic review | * |
dc.title | Antihypertensive drug use and psoriasis: A systematic review, meta- and network meta-analysis | * |
dc.type | Review | * |
dc.relation.issue | 3 | * |
dc.relation.volume | 88 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 933 | * |
dc.relation.lastpage | 941 | * |
dc.relation.journaltitle | British Journal of Clinical Pharmacology | * |
dc.identifier.doi | 10.1111/bcp.15060 | * |
dc.identifier.scopusid | 2-s2.0-85116336610 | * |
dc.author.google | Song G. | * |
dc.author.google | Yoon H.Y. | * |
dc.author.google | Yee J. | * |
dc.author.google | Kim M.G. | * |
dc.author.google | Gwak H.S. | * |
dc.contributor.scopusid | 송곤진(57208326415) | * |
dc.contributor.scopusid | 이정(56828770200) | * |
dc.contributor.scopusid | 김명규(57193132066) | * |
dc.date.modifydate | 20240422115307 | * |