Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤주영 | * |
dc.date.accessioned | 2022-03-31T16:31:26Z | - |
dc.date.available | 2022-03-31T16:31:26Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 1944-8244 | * |
dc.identifier.other | OAK-31226 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/261077 | - |
dc.description.abstract | The treatment of diseases caused by drug-resistant bacterial infections urgently requires new types of broad-spectrum antimicrobial materials. Herein, we introduce a supramolecular self-assembly, NanoPcN, which realizes the combination of type I photodynamic activity and photothermal effects by modifying zinc(II) phthalocyanine with a 3-(dimethylamino) phenoxy group. Antibacterial experiments demonstrate that this "one-for-two"property endows NanoPcN with excellent antimicrobial efficacy, not only against Gram-positive and Gram-negative bacteria but also against multidrug-resistant bacteria. An ultralow concentration of NanoPcN (50 nM) almost completely inhibited the growth of methicillin-resistant Staphylococcus aureus upon 655 nm laser irradiation (0.5 W/cm2) for 2 min, and the antibacterial effect was significantly stronger than that of the known photosensitizers methylene blue and tetraphenylporphyrin tetrasulfonic acid. Thus, the construction of "one-for-two"materials through a simple molecular structure modification paves a feasible way for the development of effective broad-spectrum antibacterial agents. © 2022 American Chemical Society. All rights reserved. | * |
dc.language | English | * |
dc.publisher | American Chemical Society | * |
dc.subject | multidrug-resistant bacteria | * |
dc.subject | one-for-two | * |
dc.subject | photodynamic therapy | * |
dc.subject | photothermal therapy | * |
dc.subject | phthalocyanine self-assembly | * |
dc.title | Phthalocyanine-Assembled "one-For-Two" Nanoparticles for Combined Photodynamic-Photothermal Therapy of Multidrug-Resistant Bacteria | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 14 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 7609 | * |
dc.relation.lastpage | 7616 | * |
dc.relation.journaltitle | ACS Applied Materials and Interfaces | * |
dc.identifier.doi | 10.1021/acsami.1c21891 | * |
dc.identifier.wosid | WOS:000758105400001 | * |
dc.identifier.scopusid | 2-s2.0-85124291699 | * |
dc.author.google | Wang R. | * |
dc.author.google | Kim D. | * |
dc.author.google | Yang M. | * |
dc.author.google | Li X. | * |
dc.author.google | Yoon J. | * |
dc.contributor.scopusid | 윤주영(7403587371) | * |
dc.date.modifydate | 20240118162450 | * |