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Photoechogenic Inflatable Nanohybrids for Upconversion-Mediated Sonotheranostics

Title
Photoechogenic Inflatable Nanohybrids for Upconversion-Mediated Sonotheranostics
Authors
Jeong, KeunsooKim, DojinKim, Hyun JunLee, Yong-DeokYoo, JounghyunJang, DohyubLee, SeokyungPark, HyeonjongKim, YoungsunSingh, AjayAhn, Dong JuneKim, Dong HaBang, JoonaKim, JungahnPrasad, Paras N.Kim, Sehoon
Ewha Authors
김동하
SCOPUS Author ID
김동하scopus
Issue Date
2021
Journal Title
ACS NANO
ISSN
1936-0851JCR Link

1936-086XJCR Link
Citation
ACS NANO vol. 15, no. 11, pp. 18394 - 18402
Keywords
ultrasoundupconversionnear-infraredmicrobubblenanohybrid
Publisher
AMER CHEMICAL SOC
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
Hybrid nanostructures are promising for ultrasound-triggered drug delivery and treatment, called sonotheranostics. Structures based on plasmonic nanoparticles for photothermal-induced microbubble inflation for ultrasound imaging exist. However, they have limited therapeutic applications because of short microbubble lifetimes and limited contrast. Photochemistry-based sonotheranostics is an attractive alternative, but building near-infrared (NIR)-responsive echogenic nanostructures for deep tissue applications is challenging because photolysis requires high-energy (UV-visible) photons. Here, we report a photochemistry-based echogenic nanoparticle for in situ NIR-controlled ultrasound imaging and ultrasound-mediated drug delivery. Our nanoparticle has an upconversion nanoparticle core and an organic shell carrying gas generator molecules and drugs. The core converts low-energy NIR photons into ultraviolet emission for photolysis of the gas generator. Carbon dioxide gases generated in the tumor-penetrated nanoparticle inflate into microbubbles for sonotheranostics. Using different NIR laser power allows dual-modal upconversion luminescence planar imaging and cross-sectional ultrasonography. Low-frequency (10 MHz) ultrasound stimulated microbubble collapse, releasing drugs deep inside the tumor through cavitation-induced transport. We believe that the photoechogenic inflatable hierarchical nanostructure approach introduced here can have broad applications for image-guided multimodal theranostics.
DOI
10.1021/acsnano.1c07898
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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