Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이민종 | * |
dc.date.accessioned | 2022-03-29T16:31:14Z | - |
dc.date.available | 2022-03-29T16:31:14Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 0954-691X | * |
dc.identifier.issn | 1473-5687 | * |
dc.identifier.other | OAK-31059 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/260998 | - |
dc.description.abstract | Background and aims Current guidelines for chronic hepatitis B (CHB) patients are to undergo surveillance for hepatocellular carcinoma (HCC) with 6-month ultrasonography. We aimed to compare detection rates of very-early-stage HCC in two groups: group A, undergoing 6-month ultrasonography versus group B, undergoing 6-month ultrasonography alternating with dynamic computed tomography (CT). Methods This retrospective study assessed 2151 CHB patients under entecavir/tenofovir therapy from 2007 to 2016. Detection rates of very-early-stage HCC were compared between groups A/B at intermediate/high risk based on platelets, age, gender-hepatitis B scores. The primary endpoint was the proportion of patients in each group with very-early-stage HCC. Cox proportional hazards model was used to assess the effect of surveillance modalities to detect very-early-stage HCC. Results Five-year cumulative HCC incidence rates in group A were 15.0% not significantly different from 18.2% in group B at high risk (P= 0.17). Detection rates of very-early-stage HCC were significantly higher in group B than in group A (P< 0.001), and surveillance using CT alternating with ultrasonography was significantly associated with detection of very-early-stage HCC (hazard ratio 3.89, P < 0.001). Among intermediate-risk patients, difference between detection rates of very-early-stage HCC in groups A and B was not significant (P = 0.30), and surveillance using CT alternating with ultrasonography was not significantly associated with detection of very-early-stage HCC (hazard ratio 1.61, P= 0.23). Conclusion In high-risk CHB patients, surveillance using CT alternating with ultrasonography led to higher detection rates of very-early-stage HCC compared to surveillance using ultrasonography. Copyright (C) 2020 Wolters Kluwer Health, Inc. All rights reserved. | * |
dc.language | English | * |
dc.publisher | LIPPINCOTT WILLIAMS & | * |
dc.publisher | WILKINS | * |
dc.subject | chronic hepatitis B | * |
dc.subject | hepatocellular carcinoma | * |
dc.subject | platelets | * |
dc.subject | age | * |
dc.subject | gender-hepatitis B | * |
dc.subject | surveillance | * |
dc.title | Individualized surveillance of chronic hepatitis B patients according to hepatocellular carcinoma risk based on PAGE-B scores | * |
dc.type | Article | * |
dc.relation.issue | 12 | * |
dc.relation.volume | 33 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 1564 | * |
dc.relation.lastpage | 1572 | * |
dc.relation.journaltitle | EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY | * |
dc.identifier.doi | 10.1097/MEG.0000000000001870 | * |
dc.identifier.wosid | WOS:000751842000016 | * |
dc.author.google | Kim, Ji Hyun | * |
dc.author.google | Kang, Seong Hee | * |
dc.author.google | Lee, Minjong | * |
dc.author.google | Choi, Hoon Sung | * |
dc.author.google | Jun, Baek Gyu | * |
dc.author.google | Kim, Tae Suk | * |
dc.author.google | Choi, Dae Hee | * |
dc.author.google | Suk, Ki Tae | * |
dc.author.google | Kim, Moon Young | * |
dc.author.google | Kim, Young Don | * |
dc.author.google | Cheon, Gab Jin | * |
dc.author.google | Baik, Soon Koo | * |
dc.author.google | Kim, Dong Joon | * |
dc.contributor.scopusid | 이민종(55917792000) | * |
dc.date.modifydate | 20231226092145 | * |