Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 나득채 | * |
dc.date.accessioned | 2022-03-29T16:30:59Z | - |
dc.date.available | 2022-03-29T16:30:59Z | - |
dc.date.issued | 2022 | * |
dc.identifier.issn | 0003-4932 | * |
dc.identifier.other | OAK-31142 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/260920 | - |
dc.description.abstract | Objective:To investigate the molecular characteristics of AGEJ compared with EAC and gastric adenocarcinoma.Summary of Background Data:Classification of AGEJ based on differential molecular characteristics between EAC and gastric adenocarcinoma has been long-standing controversy but rarely conducted due to anatomical ambiguity and epidemiologic difference.Methods:The molecular classification model with Bayesian compound covariate predictor was developed based on differential mRNA expression of EAC (N = 78) and GCFB (N = 102) from the Cancer Genome Atlas (TCGA) cohort. AGEJ/cardia (N = 48) in TCGA cohort and AGEJ/upper third GC (N = 46 pairs) in Seoul National University cohort were classified into the EAC-like or GCFB-like groups whose genomic, transcriptomic, and proteomic characteristics were compared.Results:AGEJ in both cohorts was similarly classified as EAC-like (31.2%) or GCFB-like (68.8%) based on the 400-gene classifier. The GCFB-like group showed significantly activated phosphoinositide 3-kinase-AKT signaling with decreased expression of ERBB2. The EAC-like group presented significantly different alternative splicing including the skipped exon of RPS24, a significantly higher copy number amplification including ERBB2 amplification, and increased protein expression of ERBB2 and EGFR compared with GCFB-like group. High-throughput 3D drug test using independent cell lines revealed that the EAC-like group showed a significantly better response to lapatinib than the GCFB-like group (P = 0.015).Conclusions:AGEJ was the combined entity of the EAC-like and GCFB-like groups with consistently different molecular characteristics in both Seoul National University and TCGA cohorts. The EAC-like group with a high Bayesian compound covariate predictor score could be effectively targeted by dual inhibition of ERBB2 and EGFR. © 2022 Lippincott Williams and Wilkins. All rights reserved. | * |
dc.language | English | * |
dc.publisher | Lippincott Williams and Wilkins | * |
dc.subject | adenocarcinoma | * |
dc.subject | classification | * |
dc.subject | ERBB2 | * |
dc.subject | esophagogastric junction | * |
dc.subject | esophagus | * |
dc.subject | genome | * |
dc.subject | neoplasm | * |
dc.subject | proteome | * |
dc.subject | sequencing | * |
dc.subject | stomach | * |
dc.subject | TCGA | * |
dc.subject | transcriptome | * |
dc.title | Comprehensive Molecular Characterization of Adenocarcinoma of the Gastroesophageal Junction between Esophageal and Gastric Adenocarcinomas | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 275 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 706 | * |
dc.relation.lastpage | 717 | * |
dc.relation.journaltitle | Annals of Surgery | * |
dc.identifier.doi | 10.1097/SLA.0000000000004303 | * |
dc.identifier.wosid | WOS:000766217800027 | * |
dc.identifier.scopusid | 2-s2.0-85126072576 | * |
dc.author.google | Suh Y.-S. | * |
dc.author.google | Na D. | * |
dc.author.google | Lee J.-S. | * |
dc.author.google | Chae J. | * |
dc.author.google | Kim E. | * |
dc.author.google | Jang G. | * |
dc.author.google | Lee J. | * |
dc.author.google | Min J. | * |
dc.author.google | Ock C.-Y. | * |
dc.author.google | Kong S.-H. | * |
dc.author.google | George J. | * |
dc.author.google | Zhang C. | * |
dc.author.google | Lee H.-J. | * |
dc.author.google | Kim J.-I. | * |
dc.author.google | Kim S.-J. | * |
dc.author.google | Kim W.H. | * |
dc.author.google | Lee C. | * |
dc.author.google | Yang H.-K. | * |
dc.contributor.scopusid | 나득채(37034738100) | * |
dc.date.modifydate | 20240318140645 | * |