Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김동하 | * |
dc.contributor.author | 이혁진 | * |
dc.contributor.author | Filipe Marques Mota | * |
dc.date.accessioned | 2022-03-03T16:31:07Z | - |
dc.date.available | 2022-03-03T16:31:07Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 1944-8244 | * |
dc.identifier.issn | 1944-8252 | * |
dc.identifier.other | OAK-30716 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/260821 | - |
dc.description.abstract | Despite the unique ability of lanthanide-doped upconversion nanoparticles (UCNPs) to convert near-infrared (NIR) light to high-energy UV-vis radiation, low quantum efficiency has rendered their application unpractical in biomedical fields. Here, we report anatase titania-coated plasmonic gold nanorods decorated with UCNPs (Au NR@aTiO(2)@UCNPs) for combinational photothermal and photodynamic therapy to treat cancer. Our novel architecture employs the incorporation of an anatase titanium dioxide (aTiO(2)) photosensitizer as a spacer and exploits the localized surface plasmon resonance (LSPR) properties of the Au core. The LSPR-derived near-field enhancement induces a threefold boost of upconversion emissions, which are re-absorbed by neighboring aTiO(2) and Au nanocomponents. Photocatalytic experiments strongly infer that LSPR-induced hot electrons are injected into the conduction band of aTiO(2), generating reactive oxygen species. As phototherapeutic agents, our hybrid nanostructures show remarkable in vitro anticancer effect under NIR light [28.0% cancer cell viability against Au NR@aTiO(2) (77.3%) and UCNP@aTiO(2) (98.8%)] ascribed to the efficient radical formation and LSPR-induced heat generation, with cancer cell death primarily following an apoptotic pathway. In vivo animal studies further confirm the tumor suppression ability of Au NR@aTiO(2)@UCNPs through combinatorial photothermal and photodynamic effect. Our hybrid nanomaterials emerge as excellent multifunctional phototherapy agent, providing a valuable addition to light-triggered cancer treatments in deep tissue. | * |
dc.language | English | * |
dc.publisher | AMER CHEMICAL SOC | * |
dc.subject | upconversion | * |
dc.subject | localized surface plasmon resonance | * |
dc.subject | titanium dioxide | * |
dc.subject | photosensitizer | * |
dc.subject | phototherapy | * |
dc.title | Plasmon-Triggered Upconversion Emissions and Hot Carrier Injection for Combinatorial Photothermal and Photodynamic Cancer Therapy | * |
dc.type | Article | * |
dc.relation.issue | 49 | * |
dc.relation.volume | 13 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 58422 | * |
dc.relation.lastpage | 58433 | * |
dc.relation.journaltitle | ACS APPLIED MATERIALS & INTERFACES | * |
dc.identifier.doi | 10.1021/acsami.1c21949 | * |
dc.identifier.wosid | WOS:000752977200017 | * |
dc.identifier.scopusid | 2-s2.0-85120920013 | * |
dc.author.google | Yu, Subin | * |
dc.author.google | Jang, Dohyub | * |
dc.author.google | Yuan, Hong | * |
dc.author.google | Huang, Wen-Tse | * |
dc.author.google | Kim, Minju | * |
dc.author.google | Mota, Filipe Marques | * |
dc.author.google | Liu, Ru-Shi | * |
dc.author.google | Lee, Hyukjin | * |
dc.author.google | Kim, Sehoon | * |
dc.author.google | Kim, Dong Ha | * |
dc.contributor.scopusid | 김동하(26039227400) | * |
dc.contributor.scopusid | 이혁진(55233457200) | * |
dc.contributor.scopusid | Filipe Marques Mota(55647044700;57200911209) | * |
dc.date.modifydate | 20240405125620 | * |