View : 185 Download: 0

Plasmon-Triggered Upconversion Emissions and Hot Carrier Injection for Combinatorial Photothermal and Photodynamic Cancer Therapy

Title
Plasmon-Triggered Upconversion Emissions and Hot Carrier Injection for Combinatorial Photothermal and Photodynamic Cancer Therapy
Authors
Yu, SubinJang, DohyubYuan, HongHuang, Wen-TseKim, MinjuMota, Filipe MarquesLiu, Ru-ShiLee, HyukjinKim, SehoonKim, Dong Ha
Ewha Authors
김동하이혁진Filipe Marques Mota
SCOPUS Author ID
김동하scopus; 이혁진scopus; Filipe Marques Motascopusscopus
Issue Date
2021
Journal Title
ACS APPLIED MATERIALS & INTERFACES
ISSN
1944-8244JCR Link

1944-8252JCR Link
Citation
ACS APPLIED MATERIALS & INTERFACES vol. 13, no. 49, pp. 58422 - 58433
Keywords
upconversionlocalized surface plasmon resonancetitanium dioxidephotosensitizerphototherapy
Publisher
AMER CHEMICAL SOC
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Despite the unique ability of lanthanide-doped upconversion nanoparticles (UCNPs) to convert near-infrared (NIR) light to high-energy UV-vis radiation, low quantum efficiency has rendered their application unpractical in biomedical fields. Here, we report anatase titania-coated plasmonic gold nanorods decorated with UCNPs (Au NR@aTiO(2)@UCNPs) for combinational photothermal and photodynamic therapy to treat cancer. Our novel architecture employs the incorporation of an anatase titanium dioxide (aTiO(2)) photosensitizer as a spacer and exploits the localized surface plasmon resonance (LSPR) properties of the Au core. The LSPR-derived near-field enhancement induces a threefold boost of upconversion emissions, which are re-absorbed by neighboring aTiO(2) and Au nanocomponents. Photocatalytic experiments strongly infer that LSPR-induced hot electrons are injected into the conduction band of aTiO(2), generating reactive oxygen species. As phototherapeutic agents, our hybrid nanostructures show remarkable in vitro anticancer effect under NIR light [28.0% cancer cell viability against Au NR@aTiO(2) (77.3%) and UCNP@aTiO(2) (98.8%)] ascribed to the efficient radical formation and LSPR-induced heat generation, with cancer cell death primarily following an apoptotic pathway. In vivo animal studies further confirm the tumor suppression ability of Au NR@aTiO(2)@UCNPs through combinatorial photothermal and photodynamic effect. Our hybrid nanomaterials emerge as excellent multifunctional phototherapy agent, providing a valuable addition to light-triggered cancer treatments in deep tissue.
DOI
10.1021/acsami.1c21949
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

BROWSE