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Clinical impact of left atrial enlargement in Korean patients with atrial fibrillation
- Title
- Clinical impact of left atrial enlargement in Korean patients with atrial fibrillation
- Authors
- Cho, Min Soo; Park, Hyoung-Seob; Cha, Myung-Jin; Lee, So-Ryoung; Park, Jin-Kyu; Kim, Tae-Hoon; Lee, Jung Myung; Park, Junbeom; Park, Hyung Wook; Kang, Ki-Woon; Shim, Jaemin; Uhm, Jae-Sun; Kim, Jin-Bae; Kim, Changsoo; Lee, Young Soo; Choi, Eue-Keun; Joung, Boyoung; Kim, Jun
- Ewha Authors
- 박준범
- SCOPUS Author ID
- 박준범
- Issue Date
- 2021
- Journal Title
- SCIENTIFIC REPORTS
- ISSN
- 2045-2322
- Citation
- SCIENTIFIC REPORTS vol. 11, no. 1
- Publisher
- NATURE PORTFOLIO
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- We sought to evaluate the clinical implication of LAE based on left atrial anterior-posterior (LA AP) dimension or LA volume index (LAVI) in Korean patients with atrial fibrillation (AF). We enrolled 8159 AF patients from the CODE-AF registry. The primary outcome was rate of stroke or systemic embolism (SSE). The prevalence of mild, moderate, and severe LAE by LA AP dimension was 30.6%, 18.5%, and 21.4%, and by LAVI (available in 5808 patients) was 15.7%, 12.5% and 37.8%, respectively. Compared with no or mild LAE, patients with significant LAE (moderate to severe LAE, n = 3258, 39.9%) were associated with a higher rate of SSE (2.5% vs. 1.4%, P = 0.001). Multivariable analysis suggested presence of significant LAE by LA AP dimension was associated with a higher risk of SSE in the overall population (HR 1.57, 95% CI: 1.14-2.17, P = 0.005) and in patients using anticoagulants (n = 5836, HR 1.79, 95% CI: 1.23-2.63, P = 0.002). Patients with significant LAE by LAVI were also at higher risk of SSE (HR 1.58, 95% CI: 1.09-2.29, P = 0.017). In conclusion, significant LAE by LA dimension or LAVI was present in 39.9% and 50.2% of AF patients, respectively, and was associated with a higher rate of SSE.
- DOI
- 10.1038/s41598-021-03266-z
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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