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TAZ links exercise to mitochondrial biogenesis via mitochondrial transcription factor A
- Title
- TAZ links exercise to mitochondrial biogenesis via mitochondrial transcription factor A
- Authors
- Hwang J.-H.; Kim K.M.; Oh H.T.; Yoo G.D.; Jeong M.G.; Lee H.; Park J.; Jeong K.; Kim Y.K.; Ko Y.-G.; Hwang E.S.; Hong J.-H.
- Ewha Authors
- 황은숙
- SCOPUS Author ID
- 황은숙
- Issue Date
- 2022
- Journal Title
- Nature Communications
- ISSN
- 2041-1723
- Citation
- Nature Communications vol. 13, no. 1
- Publisher
- Nature Research
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Mitochondria are energy-generating organelles and mitochondrial biogenesis is stimulated to meet energy requirements in response to extracellular stimuli, including exercise. However, the mechanisms underlying mitochondrial biogenesis remain unknown. Here, we demonstrate that transcriptional coactivator with PDZ-binding motif (TAZ) stimulates mitochondrial biogenesis in skeletal muscle. In muscle-specific TAZ-knockout (mKO) mice, mitochondrial biogenesis, respiratory metabolism, and exercise ability were decreased compared to wild-type mice. Mechanistically, TAZ stimulates the translation of mitochondrial transcription factor A via Ras homolog enriched in brain (Rheb)/Rheb like 1 (Rhebl1)-mTOR axis. TAZ stimulates Rhebl1 expression via TEA domain family transcription factor. Rhebl1 introduction by adeno-associated virus or mTOR activation recovered mitochondrial biogenesis in mKO muscle. Physiologically, mKO mice did not stimulate exercise-induced mitochondrial biogenesis. Collectively, our results suggested that TAZ is a novel stimulator for mitochondrial biogenesis and exercise-induced muscle adaptation. © 2022, The Author(s).
- DOI
- 10.1038/s41467-022-28247-2
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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