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Effects of Coffee Consumption on Insulin Resistance and Sensitivity: A Meta-Analysis

Title
Effects of Coffee Consumption on Insulin Resistance and Sensitivity: A Meta-Analysis
Authors
Moon, Su-MinJoo, Min-JinLee, Young-SeoKim, Myeong-Gyu
Ewha Authors
김명규
SCOPUS Author ID
김명규scopus
Issue Date
2021
Journal Title
NUTRIENTS
ISSN
2072-6643JCR Link
Citation
NUTRIENTS vol. 13, no. 11
Keywords
coffeemeta-analysisinsulin resistanceinsulin sensitivity
Publisher
MDPI
Indexed
SCIE; SCOPUS WOS
Document Type
Review
Abstract
Coffee is widely consumed worldwide and impacts glucose metabolism. After a previous meta-analysis that evaluated the effects of coffee consumption on insulin resistance and sensitivity, additional randomized controlled trials (RCTs) were conducted. This meta-analysis aimed to evaluate the effects of coffee consumption on insulin resistance or sensitivity. We selected RCTs that evaluated the effects of coffee consumption for seven days or more on insulin sensitivity or resistance using surrogate indices (homeostasis model assessment for insulin resistance (HOMA-IR) and Matsuda index). The fixed-effects or random-effects model was used according to heterogeneity. Four studies with 268 participants were analyzed in this meta-analysis. Coffee consumption significantly decreased HOMA-IR compared to control (mean difference (MD) = -0.13; 95% CI = -0.24--0.03; p-value = 0.01). However, the significance was not maintained in the sensitivity analysis (MD = -0.04; 95% CI = -0.18-0.10; p-value = 0.55) after excluding data from the healthy, young, normal-weight group. Matsuda index was not significantly different between coffee and control groups (standardized mean difference (SMD) = -0.33; 95% CI = -0.70-0.03; p-value = 0.08). In conclusion, long-term coffee consumption has a nonsignificant effect on insulin resistance and sensitivity. More studies evaluating the effects of coffee consumption in the healthy, young, and normal-weight individuals are needed.
DOI
10.3390/nu13113976
Appears in Collections:
약학대학 > 약학과 > Journal papers
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