Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 송은미 | - |
dc.date.accessioned | 2021-12-28T16:30:56Z | - |
dc.date.available | 2021-12-28T16:30:56Z | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 1542-3565 | - |
dc.identifier.issn | 1542-7714 | - |
dc.identifier.other | OAK-30592 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/259706 | - |
dc.description.abstract | BACKGROUND & AIMS: Long-term outcomes of constipation have not been evaluated fully. We investigated the incidence of Parkinson's disease, constipation-related surgery, and colorectal cancer (CRC) in patients with constipation and slow-transit constipation (STC), followed up for up to 20 years. METHODS: We collected data from 2165 patients (33.1% men; median patient age, 54 y; median symptom duration, 5.0 y) with a diagnosis of constipation (based on Rome II criteria) who underwent an anorectal function test and a colonic transit time study, from 2000 through 2010, at a tertiary university hospital in Seoul, South Korea. The presence of STC was determined from colonic transit time. We used the Kaplan-Meier method to analyze and compare cumulative probabilities of a new diagnosis of Parkinson's disease or CRC according to the presence of STC. The patients were followed up until the end of 2019. RESULTS: During a median follow-up period of 4.7 years (interquartile range, 0.7-8.3 y), 10 patients underwent constipation-related surgery. The cumulative probabilities of constipation-related surgery were 0.7% at 5 years and 0.8% at 10 years after a diagnosis of constipation. Twenty-nine patients (1.3%) developed Parkinson's disease; the cumulative probabilities were 0.4% at 1 year, 1.0% at 5 years, and 2.6% at 10 years after a diagnosis of constipation. At 10 years, 1.3% of patients with STC required constipation-related surgery and 3.5% of patients with STC developed Parkinson's disease; in contrast, none of the patients without STC required constipation-related surgery (P = .003), and 1.5% developed Parkinson's disease (P = .019). In multivariate analysis, patient age of 65 years or older at the diagnosis of constipation (hazard ratio, 4.834; 95% CI, 2.088-11.190) and the presence of STC (hazard ratio, 2.477; 95% CI, 1.046-5.866) were associated independently with the development of Parkinson's disease. Only 5 patients had a new diagnosis of CRC during the follow-up period. The risk of CRC did not differ significantly between patients with vs without STC (P = .575). CONCLUSIONS: In a long-term follow-up study of patients with constipation in Korea, most patients had no severe complications. However, patients older than age 65 years with a new diagnosis of STC might be considered for Parkinson's disease screening. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.subject | Gastrointestinal | - |
dc.subject | Nervous System | - |
dc.subject | Colon Cancer | - |
dc.title | Long-Term Risks of Parkinson's Disease, Surgery, and Colorectal Cancer in Patients With Slow-Transit Constipation | - |
dc.type | Article | - |
dc.relation.issue | 12 | - |
dc.relation.volume | 19 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 2577 | - |
dc.relation.lastpage | + | - |
dc.relation.journaltitle | CLINICAL GASTROENTEROLOGY AND HEPATOLOGY | - |
dc.identifier.doi | 10.1016/j.cgh.2020.08.059 | - |
dc.identifier.wosid | WOS:000753629400023 | - |
dc.identifier.scopusid | 2-s2.0-85103962355 | - |
dc.author.google | Song, Eun Mi | - |
dc.author.google | Lee, Hyo Jeong | - |
dc.author.google | Jung, Kee Wook | - |
dc.author.google | Kim, Mi Jung | - |
dc.author.google | Hwang, Sung Wook | - |
dc.author.google | Park, Sang Hyoung | - |
dc.author.google | Yang, Dong-Hoon | - |
dc.author.google | Ye, Byong Duk | - |
dc.author.google | Byeon, Jeong-Sik | - |
dc.author.google | Choe, Jaewon | - |
dc.author.google | Yang, Suk-Kyun | - |
dc.author.google | Rao, Satish S. C. | - |
dc.author.google | Myung, Seung-Jae | - |
dc.contributor.scopusid | 송은미(57193312165) | - |
dc.date.modifydate | 20230208113023 | - |