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Repeated exposure with short-term behavioral stress resolves pre-existing stress-induced depressive-like behavior in mice

Title
Repeated exposure with short-term behavioral stress resolves pre-existing stress-induced depressive-like behavior in mice
Authors
Lee, Eun-HwaPark, Jin-YoungKwon, Hye-JinHan, Pyung-Lim
Ewha Authors
한평림
SCOPUS Author ID
한평림scopus
Issue Date
2021
Journal Title
NATURE COMMUNICATIONS
ISSN
2041-1723JCR Link
Citation
NATURE COMMUNICATIONS vol. 12, no. 1
Publisher
NATURE PORTFOLIO
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Chronic stress induces maladaptive changes in the neural networks and it's associated with mood disorders. Here, the authors show that repeated exposure to short-term stress can resolve pre-existing chronic stress induced depressive-like behaviour in mice. Chronic stress induces adaptive changes in the brain via the cumulative action of glucocorticoids, which is associated with mood disorders. Here we show that repeated daily five-minute restraint resolves pre-existing stress-induced depressive-like behavior in mice. Repeated injection of glucocorticoids in low doses mimics the anti-depressive effects of short-term stress. Repeated exposure to short-term stress and injection of glucocorticoids activate neurons in largely overlapping regions of the brain, as shown by c-Fos staining, and reverse distinct stress-induced gene expression profiles. Chemogenetic inhibition of neurons in the prelimbic cortex projecting to the nucleus accumbens, basolateral amygdala, or bed nucleus of the stria terminalis results in anti-depressive effects similarly to short-term stress exposure, while only inhibition of neurons in the prelimbic cortex projecting to the bed nucleus of the stria terminalis rescues defective glucocorticoid release. In summary, we show that short-term stress can reverse adaptively altered stress gains and resolve stress-induced depressive-like behavior.
DOI
10.1038/s41467-021-26968-4
Appears in Collections:
일반대학원 > 뇌·인지과학과 > Journal papers
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