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Trajectory patterns for continuous metabolic syndrome score in childhood and the cardiovascular risk in adolescence
- Title
- Trajectory patterns for continuous metabolic syndrome score in childhood and the cardiovascular risk in adolescence
- Authors
- Choi, Eun Jeong; Lee, Hye Ah; Park, Bomi; Park, Bohyun; Kim, Hae Soon; Hong, Young Sun; Park, Hyesook
- Ewha Authors
- 김혜순; 박혜숙; 홍영선
- SCOPUS Author ID
- 김혜순; 박혜숙; 홍영선
- Issue Date
- 2021
- Journal Title
- SCIENTIFIC REPORTS
- ISSN
- 2045-2322
- Citation
- SCIENTIFIC REPORTS vol. 11, no. 1
- Publisher
- NATURE PORTFOLIO
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- We explored the association between the trajectory of the continuous metabolic syndrome score (cMetS) in childhood with high-sensitivity C-reactive protein (hs-CRP) and carotid intima-media thickness (CIMT), which are known to increase cardiovascular disease risk in adolescence. The trajectory of cMetS in childhood (from 3 to 12 years of age) was identified in 833 children who participated in the Ewha Birth and Growth Study. The associations between cMetS and hs-CRP and CIMT were analyzed in 204 out of 833 children who participated in the follow-up at 13-15 years of age and measured hs-CRP and CIMT. Among the 833 children, three groups were classified: cMetS maintained at a low level (n = 198, 23.77%), middle level (n = 530, 63.63%), and at high levels (n = 105, 12.61%). The group with a stable-high cMetS trajectory showed significantly higher hs-CRP levels, and the statistical significance was maintained after adjusting for covariates. This study found that a consistently high cMetS in childhood was significantly associated with higher hs-CRP levels in adolescents, suggesting that it is necessary to intervene in metabolic risk factors early in life to reduce the risk of cardiovascular disease later in life.
- DOI
- 10.1038/s41598-021-01566-y
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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