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Trajectory patterns for continuous metabolic syndrome score in childhood and the cardiovascular risk in adolescence

Title
Trajectory patterns for continuous metabolic syndrome score in childhood and the cardiovascular risk in adolescence
Authors
Choi E.J.Lee H.A.Park B.Kim H.S.Hong Y.S.Park H.
Ewha Authors
김혜순박혜숙홍영선
SCOPUS Author ID
김혜순scopus; 박혜숙scopus; 홍영선scopus
Issue Date
2021
Journal Title
Scientific Reports
ISSN
2045-2322JCR Link
Citation
Scientific Reports vol. 11, no. 1
Publisher
Nature Research
Indexed
SCIE; SCOPUS scopus
Document Type
Article
Abstract
We explored the association between the trajectory of the continuous metabolic syndrome score (cMetS) in childhood with high-sensitivity C-reactive protein (hs-CRP) and carotid intima-media thickness (CIMT), which are known to increase cardiovascular disease risk in adolescence. The trajectory of cMetS in childhood (from 3 to 12 years of age) was identified in 833 children who participated in the Ewha Birth and Growth Study. The associations between cMetS and hs-CRP and CIMT were analyzed in 204 out of 833 children who participated in the follow-up at 13–15 years of age and measured hs-CRP and CIMT. Among the 833 children, three groups were classified: cMetS maintained at a low level (n = 198, 23.77%), middle level (n = 530, 63.63%), and at high levels (n = 105, 12.61%). The group with a stable-high cMetS trajectory showed significantly higher hs-CRP levels, and the statistical significance was maintained after adjusting for covariates. This study found that a consistently high cMetS in childhood was significantly associated with higher hs-CRP levels in adolescents, suggesting that it is necessary to intervene in metabolic risk factors early in life to reduce the risk of cardiovascular disease later in life. © 2021, The Author(s).
DOI
10.1038/s41598-021-01566-y
Appears in Collections:
의과대학 > 의학과 > Journal papers
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