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Can corticomuscular coherence differentiate between rem sleep behavior disorder with or without parkinsonism?

Title
Can corticomuscular coherence differentiate between rem sleep behavior disorder with or without parkinsonism?
Authors
Choi G.S.Yun J.Y.Hwang S.Kim S.E.Kim J.-Y.Im C.-H.Lee H.W.
Ewha Authors
이향운윤지영
SCOPUS Author ID
이향운scopus; 윤지영scopusscopus
Issue Date
2021
Journal Title
Journal of Clinical Medicine
ISSN
2077-0383JCR Link
Citation
Journal of Clinical Medicine vol. 10, no. 23
Keywords
Electroencephalography (EEG)ParkinsonismPolysomnography (PSG)REM sleep behavior disorder
Publisher
MDPI
Indexed
SCIE; SCOPUS scopus
Document Type
Article
Abstract
REM sleep behavior disorder (RBD) could be a predictor of Parkinsonism even before development of typical motor symptoms. This study aims to characterize clinical features and corticomuscular and corticocortical coherence (CMC and CCC, respectively) during sleep in RBD patients with or without Parkinsonism. We enrolled a total of 105 subjects, including 20 controls, 54 iRBD, and 31 RBD+P patients, patients who were diagnosed as idiopathic RBD (iRBD) and RBD with Parkinsonism (RBD+P) in our neurology department. We analyzed muscle atonia index (MAI) and CMC between EEG and chin/limb muscle electromyography (EMG) and CCC during different sleep stages. Although differences in the CMC of iRBD group were observed only during REM sleep, MAI differences between groups were noted during both REM and NREM N2 stage sleep. During REM sleep, CMC was higher and MAI was reduced in iRBD patients compared to controls (p = 0.001, p < 0.001, respectively). Interestingly, MAI was more reduced in RBD+P compared to iRBD patients. In comparison, CCC was higher in iRBD patients compared to controls whereas CCC was lower in RBD+P groups compared to control and iRBD groups in various frequency bands during both NREM N2 and REM sleep stages. Among them, increased CMC during REM sleep revealed correlation between clinical severities of RBD symptoms. Our findings indicate that MAI, CMC, and CCC showed distinctive features in iRBD and RBD+P patients compared to controls, suggesting potential usefulness to understand possible links between these diseases. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
DOI
10.3390/jcm10235585
Appears in Collections:
의과대학 > 의학과 > Journal papers
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