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Potential role of ccn proteins in breast cancer: Therapeutic advances and perspectives

Title
Potential role of ccn proteins in breast cancer: Therapeutic advances and perspectives
Authors
Ahmed K.A.Hasib T.A.Paul S.K.Saddam M.Mimi A.Saikat A.S.M.Faruque H.-A.Rahman M.A.Uddin M.J.Kim B.
Ewha Authors
Md Jamal Uddin
SCOPUS Author ID
Md Jamal Uddinscopus
Issue Date
2021
Journal Title
Current Oncology
ISSN
1718-7729JCR Link
Citation
Current Oncology vol. 28, no. 6, pp. 4972 - 4985
Keywords
Breast cancerCCN proteinsProspectsTherapeutic advancesTumorigenesis
Publisher
MDPI
Indexed
SCOPUS scopus
Document Type
Review
Abstract
CCNs are a specific type of matricellular protein, which are essential signaling molecules, and play multiple roles in multicellular eukaryotes. This family of proteins consists of six separate members, which exist only in vertebrates. The architecture of CCN proteins is multi-modular com-prising four distinct modules. CCN Proteins achieve their primary functional activities by binding with several integrin7 receptors. The CCN family has been linked to cell adhesion, chemotaxis and migration, mitogenesis, cell survival, angiogenesis, differentiation, tumorigenesis, chondrogenesis, and wound healing, among other biological interactions. Breast cancer is the most commonly diagnosed cancer worldwide and CCN regulated breast cancer stands at the top. A favorable or unfa-vorable association between various CCNs has been reported in patients with breast carcinomas. The pro-tumorigenic CCN1, CCN2, CCN3, and CCN4 may lead to human breast cancer, although the anti-tumorigenic actions of CCN5 and CCN6 are also present. Several studies have been conducted on CCN proteins and cancer in recent years. CCN1 and CCN3 have been shown to exhibit a dual nature of tumor inhibition and tumor suppression to some extent in quiet recent time. Pharmacological advances in treating breast cancer by targeting CCN proteins are also reported. In our study, we intend to provide an overview of these research works while keeping breast cancer in focus. This information may facilitate early diagnosis, early prognosis and the development of new therapeutic strategies. © 2021 by the authors.
DOI
10.3390/curroncol28060417
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연구기관 > 약학연구소 > Journal papers
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