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Risk due to abo incompatibility and donor-recipient weight mismatch in living donor kidney transplantation: A national cohort study

Title
Risk due to abo incompatibility and donor-recipient weight mismatch in living donor kidney transplantation: A national cohort study
Authors
Kim D.G.Lee J.Y.Cha S.H.Kim S.H.Jeong K.H.Chung K.Y.Cho H.R.Lee J.Huh K.H.Yang J.Kim M.S.
Ewha Authors
정구용
SCOPUS Author ID
정구용scopus
Issue Date
2021
Journal Title
Journal of Clinical Medicine
ISSN
2077-0383JCR Link
Citation
Journal of Clinical Medicine vol. 10, no. 23
Keywords
ABO incompatibleKidney transplantationLiving donorWeight mismatch
Publisher
MDPI
Indexed
SCIE; SCOPUS scopus
Document Type
Article
Abstract
The effect of donor-recipient weight mismatch is not well established in ABO-incompatible living donor kidney transplantation (LDKT). A total of 2584 LDKT patients in the Korean Organ Transplantation Registry were classified into four groups according to the presence or absence of ABO incompatibility and donor-recipient weight mismatch (donor-to-recipient weight ratio (DRWR) < 0.8). In a multivariable Cox analysis, the combination of ABO incompatibility and DRWR incompatibility (n = 124) was an independent risk factor for graft survival (HR = 2.73, 95% CI = 1.11–6.70) and patient survival (HR = 3.55, 95% CI = 1.39–9.04), whereas neither factor alone was a significant risk factor for either outcome. The combination of ABO incompatibility and DRWR incompatibility was not an independent risk factor for biopsy-proven graft rejection (HR = 1.27, 95% CI = 0.88–1.82); however, it was an independent risk factor for pneumonia (HR = 2.94, 95% CI = 1.64–5.57). The mortality rate due to infection was higher among patients with both ABO incompatibility and DRWR incompatibility than among patients with neither factor or with either factor alone. The combination of ABO incompatibility and DRWR incompatibility was an independent risk factor for graft and patient survival after LDKT, whereas neither factor alone significantly affected graft or patient survival. Thus, donor-recipient weight matching should be cautiously considered in LDKT with ABO incompatibility. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
DOI
10.3390/jcm10235674
Appears in Collections:
의과대학 > 의학과 > Journal papers
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