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Effect of low protein intake on acute exacerbations in mild to moderate chronic obstructive pulmonary disease: data from the 2007-2012 KNHANES

Title
Effect of low protein intake on acute exacerbations in mild to moderate chronic obstructive pulmonary disease: data from the 2007-2012 KNHANES
Authors
Park, SojungKim, Seo WooRhee, Chin KookKim, KyungjooKim, Woo JinHa Yoo, KwangLee, Chang YoulKim, Deog KyeomPark, Yong BumJung, Ki-SuckLee, Jin Hwa
Ewha Authors
이진화박소정
SCOPUS Author ID
이진화scopus; 박소정scopusscopus
Issue Date
2021
Journal Title
JOURNAL OF THORACIC DISEASE
ISSN
2072-1439JCR Link

2077-6624JCR Link
Citation
JOURNAL OF THORACIC DISEASE vol. 13, no. 10, pp. 5592 - +
Keywords
Chronic obstructive pulmonary disease (COPD)exacerbationnutrientproteinpulmonary function
Publisher
AME PUBL CO
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
Background: Several researchers have reported that the amount of protein intake is associated with lung function and airflow obstruction. However, few studies have investigated the effect of low protein intake on acute exacerbations of chronic obstructive pulmonary disease. This study aimed to investigate the effect of low protein intake on exacerbations in mild to moderate chronic obstructive pulmonary disease. Methods: We used data obtained from the Korean National Health and Nutrition Examination Survey (KNHANES) between 2007 and 2012, linked to the National Health Insurance claims data. The clinical outcomes and the rate of exacerbation were retrospectively compared between the low protein intake group and the non-low protein intake group which was stratified by quartile categories of protein intake in 2,069 patients with mild to moderate chronic obstructive pulmonary disease. Results: The low protein intake group was significantly associated with older age, women, never smoker, low household income, and low education level, compared with the non-low protein intake group. The low protein intake group was significantly associated with increased hospitalization (18.0% vs. 10.5%, P<0.001) and emergency department utilization (1.6 +/- 1.0 vs. 1.1 +/- 0.4, P=0.033) compared with the non-low protein intake group. In multivariate analysis, the low protein intake group was associated with hospitalization (odds ratio 1.46; 95% CI, 1.09-1.96; P=0.012). The multiple linear regression analysis revealed that the amount of protein intake was associated with FVC % predicted (beta=0.048, P<0.001) and FEV1 % predicted (beta=0.022, P=0.015). Conclusions: Low protein intake was associated with an increased risk of exacerbations in mild to moderate chronic obstructive pulmonary disease. The data are available at the KNHANES website (https://knhanes.cdc.go.kr).
DOI
10.21037/jtd-20-3433
Appears in Collections:
의과대학 > 의학과 > Journal papers
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