Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 우소연 | * |
dc.contributor.author | 박장원 | * |
dc.contributor.author | 조경아 | * |
dc.contributor.author | 김유희 | * |
dc.date.accessioned | 2021-12-01T16:30:59Z | - |
dc.date.available | 2021-12-01T16:30:59Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 1107-3756 | * |
dc.identifier.issn | 1791-244X | * |
dc.identifier.other | OAK-30538 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/259621 | - |
dc.description.abstract | Mesenchymal stem cells (MSCs) are mesoderm-originated adult SCs that possess multidirectional differentiation potential. MSCs migrate to injured tissue and secrete a range of paracrine factors that induce regeneration in damaged tissue and exert immune modulation. Because tumor progression is dependent on cross-talk between the tumor and its microenvironment, MSCs also produce extra-cellular vesicles (EVs) that mediate information transfer in the tumor microenvironment. However, the effect of MSC-derived EVs on tumor development and progression is still controversial. To date, tonsil-derived MSCs (T-MSCs) have been shown to possess all the defined characteristics of MSCs and show distinctive features of differential potential and immune modulation. To observe the effect of soluble mediators from T-MSCs on tumor growth, human liver cancer cell line (HepG2) cells were injected into nude mice and HepG2 cell scratch migration assay was performed using conditioned medium (CM) of T-MSCs. T-MSC CM inhibited tumor growth and progression and it was hypothesized that EVs from T-MSCs could inhibit tumor progression. microRNA (miRNA or miR) sequencing using five different origins of T-MSC-derived EVs was performed and highly expressed miRNAs, such as miR-199a-3p, miR-214-3p, miR-199a-5p and miR-199b-5p, were selected. T-MSCs inhibited tumor growth and HepG2 cell migration, potentially via miR-199a-3p targeting CD151, integrin alpha 3 and 6 in HepG2 cells. | * |
dc.language | English | * |
dc.publisher | SPANDIDOS PUBL LTD | * |
dc.subject | tonsil-derived mesenchymal stromal cells | * |
dc.subject | microRNA | * |
dc.subject | exosome | * |
dc.subject | tumor suppression | * |
dc.title | Extracellular vesicles from tonsil-derived mesenchymal stromal cells show anti-tumor effect via miR-199a-3p | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 48 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE | * |
dc.identifier.doi | 10.3892/ijmm.2021.5054 | * |
dc.identifier.wosid | WOS:000713663900001 | * |
dc.identifier.scopusid | 2-s2.0-85122098181 | * |
dc.author.google | Choi, Da-Won | * |
dc.author.google | Cho, Kyung-Ah | * |
dc.author.google | Kim, Jungwoo | * |
dc.author.google | Lee, Hyun-Ji | * |
dc.author.google | Kim, Yu-Hee | * |
dc.author.google | Park, Jang-Won | * |
dc.author.google | Woo, So-Youn | * |
dc.contributor.scopusid | 우소연(7402853365) | * |
dc.contributor.scopusid | 박장원(55645949000) | * |
dc.contributor.scopusid | 조경아(21734204400) | * |
dc.contributor.scopusid | 김유희(15764983100) | * |
dc.date.modifydate | 20240311140754 | * |