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Aging effects on the diurnal patterns of gut microbial composition in male and female mice

Title
Aging effects on the diurnal patterns of gut microbial composition in male and female mice
Authors
Kim, Hyun-JungMoon, Chang MoKang, Jihee LeePark, Eun-Mi
Ewha Authors
이지희박은미문창모김현정
SCOPUS Author ID
이지희scopus; 박은미scopus; 문창모scopus; 김현정scopus
Issue Date
2021
Journal Title
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
ISSN
1226-4512JCR Link

2093-3827JCR Link
Citation
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY vol. 25, no. 6, pp. 575 - 583
Keywords
AgingDiurnal rhythmDysbiosisGut microbiotaSex difference
Publisher
KOREAN JOURNAL OF PHYSIOLOGY &

PHARMACOLOGY
Indexed
SCIE; SCOPUS; KCI WOS
Document Type
Article
Abstract
Composition of the gut microbiota changes with aging and plays an important role in age-associated disease such as metabolic syndrome, cancer, and neurodegeneration. The gut microbiota composition oscillates through the day, and the disruption of their diurnal rhythm results in gut dysbiosis leading to metabolic and immune dysfunctions. It is well documented that circadian rhythm changes with age in several biological functions such as sleep, body temperature, and hormone secretion. However, it is not defined whether the diurnal pattern of gut microbial composition is affected by aging. To evaluate aging effects on the diurnal pattern of the gut microbiome, we evaluated the taxa profiles of cecal contents obtained from young and aged mice of both sexes at daytime and nighttime points by 16S rRNA gene sequencing. At the phylum level, the ratio of Firmicutes to Bacteroidetes and the relative abundances of Verrucomicrobia and Cyanobacteria were increased in aged male mice at night compared with that of young male mice. Meanwhile, the relative abundances of Sutterellaceae, Alloprevotella, Lachnospiraceae UCG-001, and Parasutterella increased in aged female mice at night compared with that of young female mice. The Lachnospiraceae NK4A136 group relative abundance increased in aged mice of both sexes but at opposite time points. These results showed the changes in diurnal patterns of gut microbial composition with aging, which varied depending on the sex of the host. We suggest that disturbed diurnal patterns of the gut microbiome can be a factor for the underlying mechanism of age-associated gut dysbiosis.
DOI
10.4196/kjpp.2021.25.6.575
Appears in Collections:
의과대학 > 의학과 > Journal papers
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