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Impact of Follow-up F-18-FDG PET on the Management in Patients With Lung Cancer A Meta-analysis

Title
Impact of Follow-up F-18-FDG PET on the Management in Patients With Lung Cancer A Meta-analysis
Authors
Yoon, Hai-JeonPak, Kyoungjune
Ewha Authors
윤혜전
SCOPUS Author ID
윤혜전scopus
Issue Date
2021
Journal Title
CLINICAL NUCLEAR MEDICINE
ISSN
0363-9762JCR Link

1536-0229JCR Link
Citation
CLINICAL NUCLEAR MEDICINE vol. 46, no. 12, pp. 983 - 988
Keywords
positron emission tomographylung cancertherapyfluorodeoxyglucose
Publisher
LIPPINCOTT WILLIAMS &

WILKINS
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
Purpose The incidence of lung cancer has increased steadily. We meta-analyzed to assess the impact of F-18-FDG PET on the management of lung cancer to detect recurrence/metastasis. Materials and Methods We performed systematic searches of Medline and Embase databases for English-language publications. All published studies regarding the impact of PET on the management of patients with lung cancer in detection of recurrence/metastasis were searched. The proportion of management change (%) defined as the percentage of patients who changed management after FDG PET to patients who had FDG PET was calculated. The data from each study were analyzed using MedCalc Statistical Software version 14.12.0 (MedCalc Software, Ostend, Belgium). Results Eight studies including 523 patients were eligible for inclusion in the study. The impact of F-18-FDG PET for the purpose of detecting recurrence/metastasis in patients with lung cancer was evaluated using management change rates, which were ranged from 28.6% to 79.2% with a pooled effect of 61.4% (95% confidence interval, 49.5%-72.7%; I-2 = 85.7%). In a subgroup analysis, impact of F-18-FDG PET was evaluated in studies of patients with non-small cell lung cancer with indication of abnormal findings of conventional imaging, elevated tumor markers, and clinical symptoms with the pooled rate of management change of 62.2% (95% confidence interval, 44.2%-78.5%; I-2 = 88.0%). Conclusions We have highlighted that F-18-FDG PET has a major impact on the management of patients with recurrent lung cancer. These findings suggest that F-18-FDG PET should be performed in patients with lung cancer, especially in cases involving equivocal or suspicious recurrence/metastasis on conventional imaging, elevated tumor markers, or clinical symptoms during follow-up.
DOI
10.1097/RLU.0000000000003880
Appears in Collections:
의과대학 > 의학과 > Journal papers
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