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Impact of Multifocality on the Recurrence of Papillary Thyroid Carcinoma
- Impact of Multifocality on the Recurrence of Papillary Thyroid Carcinoma
- Woo, Joohyun; Kim, Hyeonkyeong; Kwon, Hyungju
- Ewha Authors
- 권형주; 우주현
- SCOPUS Author ID
- 권형주; 우주현
- Issue Date
- Journal Title
- JOURNAL OF CLINICAL MEDICINE
- JOURNAL OF CLINICAL MEDICINE vol. 10, no. 21
- papillary thyroid carcinoma; multifocality; recurrence
- SCIE; SCOPUS
- Document Type
- The incidence of thyroid cancer has dramatically increased over the last few decades, and up to 60% of patients have multifocal tumors. However, the prognostic impact of multifocality in patients with papillary thyroid carcinoma (PTC) remains unestablished and controversial. We evaluate whether multifocality can predict the recurrence of PTC. A total of 1249 patients who underwent total thyroidectomy for PTC at the Ewha Medical Center between March 2012 and December 2019 were reviewed. In this study, multifocality was found in 487 patients (39.0%) and the mean follow-up period was 5.5 & PLUSMN; 2.7 years. Multifocality was associated with high-risk features for recurrence, including extrathyroidal extension, lymph node metastasis, and margin involvement. After adjustment of those clinicopathological features, 10-year disease-free survival was 93.3% in patients with multifocal tumors, whereas those with unifocal disease showed 97.6% (p = 0.011). Multivariate Cox regression analysis indicated that male sex (HR 2.185, 95% CI 1.047-4.559), tumor size (HR 1.806, 95% CI 1.337-2.441), N1b LN metastasis (HR 3.603, 95% CI 1.207-10.757), and multifocality (HR 1.986, 95% CI 1.015-3.888) were independent predictors of recurrence. In conclusion, multifocality increased the risk of recurrence in patients with PTC. Patients with multifocal PTCs may need judicious treatment and follow-up approaches.
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