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Impact of Multifocality on the Recurrence of Papillary Thyroid Carcinoma

Title
Impact of Multifocality on the Recurrence of Papillary Thyroid Carcinoma
Authors
Woo, JoohyunKim, HyeonkyeongKwon, Hyungju
Ewha Authors
권형주우주현
SCOPUS Author ID
권형주scopus; 우주현scopus
Issue Date
2021
Journal Title
JOURNAL OF CLINICAL MEDICINE
ISSN
2077-0383JCR Link
Citation
JOURNAL OF CLINICAL MEDICINE vol. 10, no. 21
Keywords
papillary thyroid carcinomamultifocalityrecurrence
Publisher
MDPI
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
The incidence of thyroid cancer has dramatically increased over the last few decades, and up to 60% of patients have multifocal tumors. However, the prognostic impact of multifocality in patients with papillary thyroid carcinoma (PTC) remains unestablished and controversial. We evaluate whether multifocality can predict the recurrence of PTC. A total of 1249 patients who underwent total thyroidectomy for PTC at the Ewha Medical Center between March 2012 and December 2019 were reviewed. In this study, multifocality was found in 487 patients (39.0%) and the mean follow-up period was 5.5 & PLUSMN; 2.7 years. Multifocality was associated with high-risk features for recurrence, including extrathyroidal extension, lymph node metastasis, and margin involvement. After adjustment of those clinicopathological features, 10-year disease-free survival was 93.3% in patients with multifocal tumors, whereas those with unifocal disease showed 97.6% (p = 0.011). Multivariate Cox regression analysis indicated that male sex (HR 2.185, 95% CI 1.047-4.559), tumor size (HR 1.806, 95% CI 1.337-2.441), N1b LN metastasis (HR 3.603, 95% CI 1.207-10.757), and multifocality (HR 1.986, 95% CI 1.015-3.888) were independent predictors of recurrence. In conclusion, multifocality increased the risk of recurrence in patients with PTC. Patients with multifocal PTCs may need judicious treatment and follow-up approaches.
DOI
10.3390/jcm10215144
Appears in Collections:
의과대학 > 의학과 > Journal papers
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