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Plasma osteoprotegerin levels are associated with the presence and burden of cerebral small vessel disease in patients with acute ischemic stroke

Title
Plasma osteoprotegerin levels are associated with the presence and burden of cerebral small vessel disease in patients with acute ischemic stroke
Authors
Park, Moo-SeokChang, YoonkyungKim, Kwang-HyunPark, Jin HeeSong, Tae-Jin
Ewha Authors
김광현송태진장윤경박무석
SCOPUS Author ID
김광현scopusscopus; 송태진scopus; 장윤경scopus
Issue Date
2021
Journal Title
CLINICAL NEUROLOGY AND NEUROSURGERY
ISSN
0303-8467JCR Link

1872-6968JCR Link
Citation
CLINICAL NEUROLOGY AND NEUROSURGERY vol. 210
Keywords
OsteoprotegerinCerebral small vessel diseaseStroke
Publisher
ELSEVIER
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
Background and purpose: Osteoprotegerin (OPG) is a component of the tumor necrosis factor receptor superfamily. Several studies have shown a relationship between OPG and cardiovascular diseases. We hypothesized that there is a relationship between plasma OPG levels and cerebral small vessel disease (SVD). Methods: Patients diagnosed with their first cerebral ischemic infarction between April 2014 and March 2017 were enrolled. All the enrolled patients were evaluated through the hospital stroke protocol, including routine blood tests, brain imaging, and measuring the plasma OPG levels. The presence and burden of cerebral SVD [cerebral microbleeds (CMBs), asymptomatic lacunar infarction (ALI), high-grade perivascular space (HPVS), high-grade white matter hyperintensity (HWMH)], and total SVD score were assessed through brain magnetic resonance imaging. Results: Of the 270 patients included in our study, 158 (58.5%) were men. The mean age of the patients was 63.8 +/- 11.6 years. In multivariable analysis, plasma OPG levels were positively associated with the presence and burden of each cerebral SVD. The odds ratios (OR) of CMBs, ALI, HPVS, and HWMH for the association of OPG per standard deviation (SD) increase were 1.58 [95% confidence interval (CI), 1.09-2.27], 1.40 (95% CI, 1.04-1.88), 1.88 (95% CI, 1.27-2.78), and 1.47 (95% CI, 1.04-2.08), respectively. Plasma OPG levels were positively correlated with total SVD score (beta = 0.211, standard error = 0.061, p-value = 0.009, R2 = 0.275). Conclusions: Plasma OPG levels correlate with the presence and burden of cerebral SVD in patients with acute ischemic stroke.
DOI
10.1016/j.clineuro.2021.107010
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의과대학 > 의학과 > Journal papers
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