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Clinical significance of variable histomorphologic findings related to mucosal inflammation in negative appendectomy

Title
Clinical significance of variable histomorphologic findings related to mucosal inflammation in negative appendectomy
Authors
Choi E.Yoo Y.Kim J.M.Sung S.H.Lee D.Park S.
Ewha Authors
성순희박상희최은오김지민
SCOPUS Author ID
성순희scopus; 박상희scopus
Issue Date
2021
Journal Title
Journal of Clinical Medicine
ISSN
2077-0383JCR Link
Citation
Journal of Clinical Medicine vol. 10, no. 17
Keywords
Appendicitis inflammatory response (AIR) scoreHigh neutrophil scoreMucosal inflammationNegative appendectomySurface epithelial flattening
Publisher
MDPI
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
The aim of the study was to investigate the clinical significance of various histomorphologic findings related to mucosal inflammation in negative appendectomy. We reviewed histopathologic findings of 118 negative appendectomies and correlated them with the appendicitis inflammatory response (AIR) score and appendiceal diameter. Among 118 patients with negative appendectomy, 94 (80%), 73 (78%) and 89 (75%) patients displayed mucosal inflammation, high neutrophil score (neutrophil count ≥10/5 high power field and surface epithelial flattening, respectively. Out of 118 patients with negative appendectomy, mucosal inflammation, high neutrophil score and surface epithelial flattening were associated with higher risk group according to the appendicitis inflammatory response (AIR) score (p < 0.05, respectively). In addition, mucosal inflammation, high neutrophil score and surface epithelial flattening were frequently detected in 118 negative appendectomies, compared with 24 incidental appendectomies (p < 0.05, respectively). In an analysis of 77 negative appendectomy patients with appendiceal diameter data available, increased appendiceal diameter was positively correlated with luminal inflammation, high neutrophil score and surface epithelial flattening (p < 0.05, respectively). In conclusion, mucosal inflammation, high neutrophil score and surface epithelial flattening in negative appendectomy may be relevant to patients’ signs and symptoms, especially in cases with no other cause of the abdominal pain. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
DOI
10.3390/jcm10174030
Appears in Collections:
의과대학 > 의학과 > Journal papers
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