Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 문영철 | * |
dc.date.accessioned | 2021-11-17T16:31:16Z | - |
dc.date.available | 2021-11-17T16:31:16Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 0513-5796 | * |
dc.identifier.issn | 1976-2437 | * |
dc.identifier.other | OAK-27173 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/259567 | - |
dc.description.abstract | Purpose: Allogeneic hematopoietic stem cell transplantation (HSCT) with optimal conditioning has helped better long-term survival in acute lymphoblastic leukemia (ALL). This study investigated the efficacy and safety of reduced-intensity conditioning (RIC) with busulfan and fludarabine in adult ALL patients unfit for myeloablation. Materials and Methods: Records of 78 patients who underwent HSCT with RIC consisting of 3.2 mg/kg/day of busulfan for 2 or 3 days and 30 mg/m(2)/day of fludarabine for 5 or 6 days were analyzed. Results: The median age at diagnosis was 49 years. Over a median follow-up of 22 months, 2-year estimates of relapse-free survival (RFS) and overall survival were 57.4% and 68.7%, respectively. Multivariate analysis showed a trend of improved RFS in patients with chronic graft-versus-host disease (GVHD) (hazard ratio, 0.53; 95% confidence interval, 0.26-1.08; p=0.080). The cumulative incidences of relapse and non-relapse mortality were 42.9% and 19.6%, respectively and one case of central nervous system relapse was noted. No hepatic veno-occlusive disease was reported. Grade II-IV acute GVHD and any grade chronic GVHD occurred in 21.1% and 41.7%, respectively. Conclusion: RIC with busulfan and fludarabine is an effective and safe conditioning regimen for adult ALL patients unfit for myeloablation. | * |
dc.language | English | * |
dc.publisher | YONSEI UNIV COLL MEDICINE | * |
dc.subject | Fludarabine | * |
dc.subject | busulfan | * |
dc.subject | lymphoblastic leukemia | * |
dc.subject | stem cell transplantation | * |
dc.subject | transplantation conditioning | * |
dc.title | Reduced-Intensity Conditioning with Busulfan and Fludarabine for Allogeneic Hematopoietic Stem Cell Transplantation in Acute Lymphoblastic Leukemia | * |
dc.type | Article | * |
dc.relation.issue | 6 | * |
dc.relation.volume | 61 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.index | KCI | * |
dc.relation.startpage | 452 | * |
dc.relation.lastpage | 459 | * |
dc.relation.journaltitle | YONSEI MEDICAL JOURNAL | * |
dc.identifier.doi | 10.3349/ymj.2020.61.6.452 | * |
dc.identifier.wosid | WOS:000537346300002 | * |
dc.author.google | Lee, Seung-Shin | * |
dc.author.google | Jung, Sung-Hoon | * |
dc.author.google | Do, Young Rok | * |
dc.author.google | Kim, Dae Sik | * |
dc.author.google | Lee, Ji Hyun | * |
dc.author.google | Park, Han-Seung | * |
dc.author.google | Moon, Joon Ho | * |
dc.author.google | Yi, Jun Ho | * |
dc.author.google | Park, Yong | * |
dc.author.google | Koh, Youngil | * |
dc.author.google | Yhim, Ho-Young | * |
dc.author.google | Choi, Yunsuk | * |
dc.author.google | Mun, Yeung-Chul | * |
dc.author.google | Lee, Won-Sik | * |
dc.author.google | Lee, Seok | * |
dc.author.google | Yang, Deok-Hwan | * |
dc.contributor.scopusid | 문영철(7003363716) | * |
dc.date.modifydate | 20240422115947 | * |