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Reduced-Intensity Conditioning with Busulfan and Fludarabine for Allogeneic Hematopoietic Stem Cell Transplantation in Acute Lymphoblastic Leukemia

Title
Reduced-Intensity Conditioning with Busulfan and Fludarabine for Allogeneic Hematopoietic Stem Cell Transplantation in Acute Lymphoblastic Leukemia
Authors
Mun, Yeung-ChulLee, Won-SikLee, SeokYang, Deok-HwanLee, Seung-ShinJung, Sung-HoonDo, Young RokKim, Dae SikLee, Ji HyunPark, Han-SeungMoon, Joon HoYi, Jun HoPark, YongKoh, YoungilYhim, Ho-YoungChoi, Yunsuk
Ewha Authors
문영철
SCOPUS Author ID
문영철scopus
Issue Date
2020
Journal Title
YONSEI MEDICAL JOURNAL
ISSN
0513-5796JCR Link

1976-2437JCR Link
Citation
YONSEI MEDICAL JOURNAL vol. 61, no. 6, pp. 452 - 459
Keywords
Fludarabinebusulfanlymphoblastic leukemiastem cell transplantationtransplantation conditioning
Publisher
YONSEI UNIV COLL MEDICINE
Indexed
SCIE; SCOPUS; KCI WOS
Document Type
Article
Abstract
Purpose: Allogeneic hematopoietic stem cell transplantation (HSCT) with optimal conditioning has helped better long-term survival in acute lymphoblastic leukemia (ALL). This study investigated the efficacy and safety of reduced-intensity conditioning (RIC) with busulfan and fludarabine in adult ALL patients unfit for myeloablation. Materials and Methods: Records of 78 patients who underwent HSCT with RIC consisting of 3.2 mg/kg/day of busulfan for 2 or 3 days and 30 mg/m(2)/day of fludarabine for 5 or 6 days were analyzed. Results: The median age at diagnosis was 49 years. Over a median follow-up of 22 months, 2-year estimates of relapse-free survival (RFS) and overall survival were 57.4% and 68.7%, respectively. Multivariate analysis showed a trend of improved RFS in patients with chronic graft-versus-host disease (GVHD) (hazard ratio, 0.53; 95% confidence interval, 0.26-1.08; p=0.080). The cumulative incidences of relapse and non-relapse mortality were 42.9% and 19.6%, respectively and one case of central nervous system relapse was noted. No hepatic veno-occlusive disease was reported. Grade II-IV acute GVHD and any grade chronic GVHD occurred in 21.1% and 41.7%, respectively. Conclusion: RIC with busulfan and fludarabine is an effective and safe conditioning regimen for adult ALL patients unfit for myeloablation.
DOI
10.3349/ymj.2020.61.6.452
Appears in Collections:
의과대학 > 의학과 > Journal papers
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