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Minimally Invasive Versus Open Pancreatectomy for Right-Sided and Left-Sided G1/G2 Nonfunctioning Pancreatic Neuroendocrine Tumors: A Multicenter Matched Analysis with an Inverse Probability of Treatment-Weighting Method
- Title
- Minimally Invasive Versus Open Pancreatectomy for Right-Sided and Left-Sided G1/G2 Nonfunctioning Pancreatic Neuroendocrine Tumors: A Multicenter Matched Analysis with an Inverse Probability of Treatment-Weighting Method
- Authors
- Hwang H.K.; Song K.B.; Park M.; Kwon W.; Jang J.-Y.; Heo J.S.; Choi D.W.; Kang C.M.; Park J.S.; Hong T.H.; Cho C.K.; Ahn K.S.; Lee H.; Lee S.E.; Jeong C.-Y.; Roh Y.H.; Kim H.J.; Hwang D.W.; Kim S.C.; Han H.-S.; Yoon Y.-S.; Choi I.S.; Kim S.-W.; Lee W.J.; Han I.W.; Yoon D.S.; Kang K.J.; Min S.K.; Lee H.K.; Hong S.C.; for the Korean Pancreas Surgery Club
- Ewha Authors
- 이희성
- SCOPUS Author ID
- 이희성
- Issue Date
- 2021
- Journal Title
- Annals of Surgical Oncology
- ISSN
- 1068-9265
- Citation
- Annals of Surgical Oncology vol. 28, no. 12, pp. 7742 - 7758
- Publisher
- Springer Science and Business Media Deutschland GmbH
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Background: Limited evidence exists for the safety and oncologic efficacy of minimally invasive surgery (MIS) for nonfunctioning pancreatic neuroendocrine tumors (NF-PNETs) according to tumor location. This study aimed to compare the surgical outcomes of MIS and open surgery (OS) for right- or left-sided NF-PNETs. Methods: The study collected data on patients who underwent surgical resection (pancreatoduodenectomy, distal/total/central pancreatectomy, duodenum-preserving pancreas head resection, or enucleation) of a localized NF-PNET between January 2000 and July 2017 at 14 institutions. The inverse probability of treatment-weighting method with propensity scores was used for analysis. Results: The study enrolled 859 patients: 478 OS and 381 MIS patients. A matched analysis by tumor location showed no differences in resection margin, intraoperative blood loss, or complications between MIS and OS. However, MIS was associated with a longer operation time for right-sided tumors (393.3 vs 316.7 min; P < 0.001) and a shorter postoperative hospital stay for left-sided tumors (8.9 vs 12.9 days; P < 0.01). The MIS group was associated with significantly higher survival rates than the OS group for right- and left-sided tumors, but survival did not differ for the patients divided by tumor grade and location. Multivariable analysis showed that MIS did not affect survival for any tumor location. Conclusion: The short-term outcomes offered by MIS were comparable with those of OS except for a longer operation time for right-sided NF-PNETs. The oncologic outcomes were not compromised by MIS regardless of tumor location or grade. These findings suggest that MIS can be performed safely for selected patients with localized NF-PNETs. © 2021, Society of Surgical Oncology.
- DOI
- 10.1245/s10434-021-10092-0
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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