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Association between polyvascular disease and clinical outcomes in patients with cardiogenic shock: Results from the RESCUE registry

Title
Association between polyvascular disease and clinical outcomes in patients with cardiogenic shock: Results from the RESCUE registry
Authors
Jang W.J.Park I.H.Yang J.H.Chun W.J.Oh J.H.Park Y.H.Ko Y.-G.Yu C.W.Kim H.-J.Kim B.S.Lee H.J.Jeong J.-O.Gwon H.-C.
Ewha Authors
장우진
SCOPUS Author ID
장우진scopus
Issue Date
2021
Journal Title
International Journal of Cardiology
ISSN
0167-5273JCR Link
Citation
International Journal of Cardiology vol. 339, pp. 70 - 74
Keywords
Cardiogenic shockPolyvascular diseasePrognosis
Publisher
Elsevier Ireland Ltd
Indexed
SCIE; SCOPUS scopus
Document Type
Article
Abstract
Background: Clinical implications of systemic atherosclerosis in patients with cardiogenic shock (CS) remain unclear. This study investigated the association between polyvascular disease (PVD) and clinical outcome in CS patients. Methods: A total of 1247 CS patients was enrolled from the RESCUE registry, a multicenter, observational cohort between January 2014 and December 2018. They were divided into two groups according to presence of PVD, defined as ≥2 coexistence of coronary artery disease, peripheral arterial disease, or cerebrovascular disease. Primary outcome was all-cause death during 12 months of follow-up. Results: 136 (10.9%) patients were diagnosed with PVD. The risk of 12-month all-cause death was significantly higher in the PVD group than in the non-PVD group (54.4% versus 40.4%, adjusted hazard ratio [HR] 1.31, 95% confidence interval [CI] 1.02–1.69, p = 0.034). There was a significant interaction between PVD and vasoactive inotropic score (VIS) (p for interaction = 0.014). Among the 945 patients with VIS <84, PVD was associated with a higher risk of 12-month all-cause death (unadjusted HR 1.77, 95% CI 1.30–2.41, p = 0.030); among the 302 patients with VIS ≥84, the incidence of 12-month all-cause death was similar between the PVD and non-PVD groups (unadjusted HR 1.03, 95% CI 0.68–1.56, p = 0.301). Conclusions: Presence of PVD was associated with 12-month all-cause mortality in patients with CS, especially for less severe forms of CS patients with VIS <84. Clinical trials.gov number: NCT02985008 © 2021 Elsevier B.V.
DOI
10.1016/j.ijcard.2021.07.008
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의료원 > 의료원 > Journal papers
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