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Association between polyvascular disease and clinical outcomes in patients with cardiogenic shock: Results from the RESCUE registry
- Association between polyvascular disease and clinical outcomes in patients with cardiogenic shock: Results from the RESCUE registry
- Jang W.J.; Park I.H.; Yang J.H.; Chun W.J.; Oh J.H.; Park Y.H.; Ko Y.-G.; Yu C.W.; Kim H.-J.; Kim B.S.; Lee H.J.; Jeong J.-O.; Gwon H.-C.
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- International Journal of Cardiology
- International Journal of Cardiology vol. 339, pp. 70 - 74
- Cardiogenic shock; Polyvascular disease; Prognosis
- Elsevier Ireland Ltd
- SCIE; SCOPUS
- Document Type
- Background: Clinical implications of systemic atherosclerosis in patients with cardiogenic shock (CS) remain unclear. This study investigated the association between polyvascular disease (PVD) and clinical outcome in CS patients. Methods: A total of 1247 CS patients was enrolled from the RESCUE registry, a multicenter, observational cohort between January 2014 and December 2018. They were divided into two groups according to presence of PVD, defined as ≥2 coexistence of coronary artery disease, peripheral arterial disease, or cerebrovascular disease. Primary outcome was all-cause death during 12 months of follow-up. Results: 136 (10.9%) patients were diagnosed with PVD. The risk of 12-month all-cause death was significantly higher in the PVD group than in the non-PVD group (54.4% versus 40.4%, adjusted hazard ratio [HR] 1.31, 95% confidence interval [CI] 1.02–1.69, p = 0.034). There was a significant interaction between PVD and vasoactive inotropic score (VIS) (p for interaction = 0.014). Among the 945 patients with VIS <84, PVD was associated with a higher risk of 12-month all-cause death (unadjusted HR 1.77, 95% CI 1.30–2.41, p = 0.030); among the 302 patients with VIS ≥84, the incidence of 12-month all-cause death was similar between the PVD and non-PVD groups (unadjusted HR 1.03, 95% CI 0.68–1.56, p = 0.301). Conclusions: Presence of PVD was associated with 12-month all-cause mortality in patients with CS, especially for less severe forms of CS patients with VIS <84. Clinical trials.gov number: NCT02985008 © 2021 Elsevier B.V.
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