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Comparison of ei‐gc‐ms/ms, apci‐lc‐ms/ms, and esi‐lc‐ms/ms for the simultaneous analysis of nine nitrosamines eluted from synthetic resins into artificial saliva and health risk assessment

Title
Comparison of ei‐gc‐ms/ms, apci‐lc‐ms/ms, and esi‐lc‐ms/ms for the simultaneous analysis of nine nitrosamines eluted from synthetic resins into artificial saliva and health risk assessment
Authors
Kim H.Sung D.Yu H.Jang D.Koo Y.Lee S.Lim K.Choi D.
Ewha Authors
임경민
SCOPUS Author ID
임경민scopus
Issue Date
2021
Journal Title
Toxics
ISSN
2305-6304JCR Link
Citation
Toxics vol. 9, no. 10
Keywords
Gas chromatography‐tandem mass spectrometryLiquid chromatography‐tandem mass spectrometryMethod validationNitrosaminesRisk assessment
Publisher
MDPI
Indexed
SCIE; SCOPUS scopus
Document Type
Article
Abstract
Nitrosamines can be produced during the manufacture of rubber‐type products such as pacifiers or the nipples of baby bottles. Humans can be exposed to the nitrosamines in these products when they are eluted into saliva. In this study, we compared the efficiency of electron impact ionization (EI), atmospheric pressure chemical ionization (APCI), and electrospray ionization (ESI) methods for the analysis of nine nitrosamines eluted into artificial saliva. In addition, nine nitrosamines eluted from 54 rubber‐type products (rubber, thermoplastic elastomer, thermoplastic polyurethane, and polyurethane) marketed in Korea were monitored. Finally, non‐carcinogenic and carcinogenic risk assessments of oral exposure to nine nitrosamines were performed based on the monitoring results. EI‐GC‐MS/MS performed the best for the simultaneous analysis of these nine nitrosamines with respect to overall linearity, trace analysis limit of detection (less than 1 μg), recovery (average 108.66 ± 9.32%), and precision (less than 6%), compared with liquid chromatography‐tandem mass spectrometry (LC‐MS/MS) (APCI and ESI) methods. Using the EI‐GC‐MS/MS method, these nine nitrosamines eluted into artificial saliva from 54 rubber‐type products were monitored. Based on the monitoring data, risk assessment was performed by calculating the margin of exposure (MOE) for the respective nitrosamines detected. As a result, these nitrosamines were confirmed to be safe with regard to both non‐carcinogenic and carcinogenic risks. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
DOI
10.3390/toxics9100230
Appears in Collections:
약학대학 > 약학과 > Journal papers
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