Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이혁진 | * |
dc.contributor.author | 박소정 | * |
dc.contributor.author | 김찬진 | * |
dc.contributor.author | 정은혜 | * |
dc.date.accessioned | 2021-11-10T16:31:14Z | - |
dc.date.available | 2021-11-10T16:31:14Z | - |
dc.date.issued | 2021 | * |
dc.identifier.issn | 2040-3364 | * |
dc.identifier.issn | 2040-3372 | * |
dc.identifier.other | OAK-30043 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/259368 | - |
dc.description.abstract | Here, we report how the nature of the hydrophobic core affects the molecular interactions of DNA block copolymer assemblies. Three different amphiphilic DNA block copolymers, DNA-b-polystyrene (DNA-b-PS), DNA-b-poly(2-vinylpyridine) (DNA-b-P2VP), and DNA-b-poly(methyl acrylate) (DNA-b-PMA) were synthesized and assembled into spherical micelles composed of a hydrophobic polymer core and DNA corona. Interestingly, DNA block copolymer micelles having different hydrophobic cores exhibited markedly different molecular and biological interactions. DNA-b-PS exhibited higher melting temperature, sharper melting transition, higher stability to nuclease-catalyzed DNA degradation, and higher cellular uptake efficiency compared to DNA-b-P2VP and DNA-b-PMA. The investigation of the self-assembly behavior revealed a much higher aggregation number and DNA density for DNA-b-PS micelles, which explains the superior properties of DNA-b-PS. These results demonstrate that the type of the hydrophobic core polymer, which has been largely overlooked, has a profound impact on the molecular and biological interactions of the DNA shell. | * |
dc.language | English | * |
dc.publisher | ROYAL SOC CHEMISTRY | * |
dc.title | The core composition of DNA block copolymer micelles dictates DNA hybridization properties, nuclease stabilities, and cellular uptake efficiencies | * |
dc.type | Article | * |
dc.relation.issue | 32 | * |
dc.relation.volume | 13 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 13758 | * |
dc.relation.lastpage | 13763 | * |
dc.relation.journaltitle | NANOSCALE | * |
dc.identifier.doi | 10.1039/d1nr00756d | * |
dc.identifier.wosid | WOS:000680833300001 | * |
dc.author.google | Kim, Chan-Jin | * |
dc.author.google | Kim, Ga-Hyun | * |
dc.author.google | Jeong, Eun Hye | * |
dc.author.google | Lee, Hyukjin | * |
dc.author.google | Park, So-Jung | * |
dc.contributor.scopusid | 이혁진(55233457200) | * |
dc.contributor.scopusid | 박소정(7501832353) | * |
dc.contributor.scopusid | 김찬진(57192071653) | * |
dc.contributor.scopusid | 정은혜(55951357800) | * |
dc.date.modifydate | 20240405125644 | * |