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Prospective Pharmacological Potential of Resveratrol in Delaying Kidney Aging

Title
Prospective Pharmacological Potential of Resveratrol in Delaying Kidney Aging
Authors
Uddin, Md JamalFarjana, MithilaMoni, AkhiHossain, Khandkar ShaharinaHannan, Md AbdulHa, Hunjoo
Ewha Authors
하헌주Md Jamal Uddin
SCOPUS Author ID
하헌주scopus; Md Jamal Uddinscopus
Issue Date
2021
Journal Title
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN
1422-0067JCR Link
Citation
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES vol. 22, no. 15
Keywords
antioxidantanti-agingAKICKDkidney agingresveratrol
Publisher
MDPI
Indexed
SCIE; SCOPUS WOS
Document Type
Review
Abstract
Aging is an unavoidable part of life. The more aged we become, the more susceptible we become to various complications and damages to the vital organs, including the kidneys. The existing drugs for kidney diseases are mostly of synthetic origins; thus, natural compounds with minimal side-effects have attracted growing interest from the scientific community and pharmaceutical companies. A literature search was carried out to collect published research information on the effects of resveratrol on kidney aging. Recently, resveratrol has emerged as a potential anti-aging agent. This versatile polyphenol exerts its anti-aging effects by intervening in various pathologies and multi-signaling systems, including sirtuin type 1, AMP-activated protein kinase, and nuclear factor-kappa B. Researchers are trying to figure out the detailed mechanisms and possible resveratrol-mediated interventions in divergent pathways at the molecular level. This review highlights (i) the causative factors implicated in kidney aging and the therapeutic aspects of resveratrol, and (ii) the effectiveness of resveratrol in delaying the aging process of the kidney while minimizing all possible side effects.
DOI
10.3390/ijms22158258
Appears in Collections:
약학대학 > 약학과 > Journal papers
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