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Association Between the CYP2C9 Genotype and Hypoglycemia Among Patients With Type 2 Diabetes Receiving Sulfonylurea Treatment: A Meta-analysis

Title
Association Between the CYP2C9 Genotype and Hypoglycemia Among Patients With Type 2 Diabetes Receiving Sulfonylurea Treatment: A Meta-analysis
Authors
Yee, JeongHeo, YunheeKim, HaminYoon, Ha YoungSong, GonjinGwak, Hye Sun
Ewha Authors
곽혜선송곤진
SCOPUS Author ID
곽혜선scopus; 송곤진scopus
Issue Date
2021
Journal Title
CLINICAL THERAPEUTICS
ISSN
0149-2918JCR Link

1879-114XJCR Link
Citation
CLINICAL THERAPEUTICS vol. 43, no. 5, pp. 836 - +
Keywords
CYP2C9hypoglycemiapolymorphismsulfonylureatype 2 diabetes
Publisher
ELSEVIER
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
Purpose: Two common variants, CYP2C9*2 (Arg144Cys, rs1799853) and CYP2C9*3 (Ile359Leu, rs1057910), are known to reduce the catalytic function of the CYP2C9 enzyme. Because impaired catalytic function is likely to affect sulfonylurea metabolism, it is predictable that CYP2C9 loss-of-function alleles may increase the risk of sulfonylurea-induced hypoglycemia. This systematic review and meta-analysis aimed to assess the association between CYP2C9 genotype and hypoglycemia among patients with type 2 diabetes mellitus (T2DM) receiving sulfonylurea. Methods: We searched for studies on the association between CYP2C9 genotype and sulfonylurea-induced hypoglycemia among patients with T2DM, published through August 7, 2020, using PubMed, Web of Science, and EMBASE. Odds ratios (ORs) and 95% CIs were calculated. Findings: Five cohort studies and 2 case-control studies were included, and the total number of patients analyzed in this meta-analysis was 2769. The CYP2C9 variant alleles were associated with an increase in sulfonylurea-induced hypoglycemia compared with wild-type homozygote (OR = 1.24; 95% CI, 1.03-1.48). Compared with CYP2C9 wild-type homozygotes, CYP2C9*2 allele was associated with increased incidence of hypoglycemia (OR = 1.85; 95% CI, 1.18-2.89), whereas the CYP2C9*3 allele failed to show the statistical significance (OR = 1.67; 95% CI, 0.40-6.86; P = 0.48). (C) 2021 Elsevier Inc.
DOI
10.1016/j.clinthera.2021.03.008
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약학대학 > 약학과 > Journal papers
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