View : 36 Download: 0
Acremonamide, a Cyclic Pentadepsipeptide with Wound-Healing Properties Isolated from a Marine-Derived Fungus of the Genus Acremonium
- Acremonamide, a Cyclic Pentadepsipeptide with Wound-Healing Properties Isolated from a Marine-Derived Fungus of the Genus Acremonium
- Kim, Sojeong; Lee, Chang Wook; Park, So-Yeon; Asolkar, Ratnakar N.; Kim, Haerin; Kim, Geum Jin; Oh, Song Jin; Kim, Youngbae; Lee, Eun-Young; Oh, Dong-Chan; Yang, Inho; Paik, Man Jeong; Choi, Hyukjae; Kim, Hangun; Nam, Sang-Jip; Fenical, William
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- JOURNAL OF NATURAL PRODUCTS vol. 84, no. 8, pp. 2249 - 2255
- AMER CHEMICAL SOC
- SCIE; SCOPUS
- Document Type
- Acremonamide (1) was isolated from a marine-derived fungus belonging to the genus Acremonium. The chemical structure of 1 was established using MS, UV, and NMR spectroscopic data analyses. Acremonamide (1) was found to contain N-Me-Phe, N-Me-Ala, Val, Phe, and 2-hydroxyisovaleric acid. The absolute configurations of the four aforementioned amino acids were determined through acid hydrolysis followed by the advanced Marfey's method, whereas the absolute configuration of 2-hydroxyisovaleric acid was determined through GC-MS analysis after formation of the O-pentafluoropropionylated derivative of the (-)-menthyl ester of 2-hydroxyisovaleric acid. As an intrinsic biological activity, acremonamide (1) did not exert cytotoxicity to cancer and noncancer cells and increased the migration and invasion. Based on these activities, the wound healing properties of acremonamide (1) were confirmed in vitro and in vivo.
- Appears in Collections:
- 자연과학대학 > 화학·나노과학전공 > Journal papers
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.