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Acremonamide, a Cyclic Pentadepsipeptide with Wound-Healing Properties Isolated from a Marine-Derived Fungus of the Genus Acremonium

Title
Acremonamide, a Cyclic Pentadepsipeptide with Wound-Healing Properties Isolated from a Marine-Derived Fungus of the Genus Acremonium
Authors
Kim, SojeongLee, Chang WookPark, So-YeonAsolkar, Ratnakar N.Kim, HaerinKim, Geum JinOh, Song JinKim, YoungbaeLee, Eun-YoungOh, Dong-ChanYang, InhoPaik, Man JeongChoi, HyukjaeKim, HangunNam, Sang-JipFenical, William
Ewha Authors
남상집
SCOPUS Author ID
남상집scopusscopus
Issue Date
2021
Journal Title
JOURNAL OF NATURAL PRODUCTS
ISSN
0163-3864JCR Link

1520-6025JCR Link
Citation
JOURNAL OF NATURAL PRODUCTS vol. 84, no. 8, pp. 2249 - 2255
Publisher
AMER CHEMICAL SOC
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
Acremonamide (1) was isolated from a marine-derived fungus belonging to the genus Acremonium. The chemical structure of 1 was established using MS, UV, and NMR spectroscopic data analyses. Acremonamide (1) was found to contain N-Me-Phe, N-Me-Ala, Val, Phe, and 2-hydroxyisovaleric acid. The absolute configurations of the four aforementioned amino acids were determined through acid hydrolysis followed by the advanced Marfey's method, whereas the absolute configuration of 2-hydroxyisovaleric acid was determined through GC-MS analysis after formation of the O-pentafluoropropionylated derivative of the (-)-menthyl ester of 2-hydroxyisovaleric acid. As an intrinsic biological activity, acremonamide (1) did not exert cytotoxicity to cancer and noncancer cells and increased the migration and invasion. Based on these activities, the wound healing properties of acremonamide (1) were confirmed in vitro and in vivo.
DOI
10.1021/acs.jnatprod.1c00305
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자연과학대학 > 화학·나노과학전공 > Journal papers
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