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6.5-GHz Brain Stimulation System Using Enhanced Probe Focusing and Switch-Driven Modulation

Title
6.5-GHz Brain Stimulation System Using Enhanced Probe Focusing and Switch-Driven Modulation
Authors
Oh, SeongwoogJung, DaheeSeo, TaeyoonHuh, YeowoolCho, JeiwonOh, Jungsuek
Ewha Authors
조제원
SCOPUS Author ID
조제원scopus
Issue Date
2021
Journal Title
IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES
ISSN
0018-9480JCR Link

1557-9670JCR Link
Citation
IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES vol. 69, no. 9, pp. 4107 - 4117
Keywords
ProbesBrain stimulationVoltage-controlled oscillatorsMicrowave oscillatorsMicrowave theory and techniquesMicrowave circuitsTransistorsBrain stimulation systemmicrowave circuitsneural probeneuromodulationprobesstimulation system
Publisher
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
This article, for the first time, presents the design, fabrication, and measurement results of a novel microwave brain stimulation system enabling efficient probe focusing of rectangular-pulse enveloped 6.5-GHz waves. While the conventional ON/OFF stimulation systems in literature employ low frequencies below 0.5 GHz, the proposed system employs 6.5 GHz that can achieve more spatial energy focusing and a moderate level of energy penetration depth. In the proposed system, the ON/OFF modulated microwave signal is generated by a single chip consisting of a voltage-controlled oscillator (VCO) and power amplifier (PA). The VCO is driven by a switch at the current source to generate modulated signals with over 20-dB isolation between the high and low states. The probe with a center-opened aperture surrounded by a symmetric loading enables low power reflection toward the brain and focuses the field in the square-shaped aperture of 1-mm(2) area. Finally, it is demonstrated that the 20-min stimulation of an in vivo mouse brain using microwave signals with 1-Hz repetitive pulse envelopes and 1% duty cycle enables the normalized firing rate to reach up to 0.2 while the normalized firing rate stays just within +/- 0.05 under no stimulation. This suggests that the proposed brain stimulation system can achieve a dramatic change in the activity of individual hippocampal neurons.
DOI
10.1109/TMTT.2021.3075726
Appears in Collections:
일반대학원 > 뇌·인지과학과 > Journal papers
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