View : 600 Download: 0
6.5-GHz Brain Stimulation System Using Enhanced Probe Focusing and Switch-Driven Modulation
- Title
- 6.5-GHz Brain Stimulation System Using Enhanced Probe Focusing and Switch-Driven Modulation
- Authors
- Oh, Seongwoog; Jung, Dahee; Seo, Taeyoon; Huh, Yeowool; Cho, Jeiwon; Oh, Jungsuek
- Ewha Authors
- 조제원
- SCOPUS Author ID
- 조제원
- Issue Date
- 2021
- Journal Title
- IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES
- ISSN
- 0018-9480
1557-9670
- Citation
- IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES vol. 69, no. 9, pp. 4107 - 4117
- Keywords
- Probes; Brain stimulation; Voltage-controlled oscillators; Microwave oscillators; Microwave theory and techniques; Microwave circuits; Transistors; Brain stimulation system; microwave circuits; neural probe; neuromodulation; probes; stimulation system
- Publisher
- IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- This article, for the first time, presents the design, fabrication, and measurement results of a novel microwave brain stimulation system enabling efficient probe focusing of rectangular-pulse enveloped 6.5-GHz waves. While the conventional ON/OFF stimulation systems in literature employ low frequencies below 0.5 GHz, the proposed system employs 6.5 GHz that can achieve more spatial energy focusing and a moderate level of energy penetration depth. In the proposed system, the ON/OFF modulated microwave signal is generated by a single chip consisting of a voltage-controlled oscillator (VCO) and power amplifier (PA). The VCO is driven by a switch at the current source to generate modulated signals with over 20-dB isolation between the high and low states. The probe with a center-opened aperture surrounded by a symmetric loading enables low power reflection toward the brain and focuses the field in the square-shaped aperture of 1-mm(2) area. Finally, it is demonstrated that the 20-min stimulation of an in vivo mouse brain using microwave signals with 1-Hz repetitive pulse envelopes and 1% duty cycle enables the normalized firing rate to reach up to 0.2 while the normalized firing rate stays just within +/- 0.05 under no stimulation. This suggests that the proposed brain stimulation system can achieve a dramatic change in the activity of individual hippocampal neurons.
- DOI
- 10.1109/TMTT.2021.3075726
- Appears in Collections:
- 일반대학원 > 뇌·인지과학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML