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Firefighters Have Cerebral Blood Flow Reductions in the Orbitofrontal and Insular Cortices That are Associated with Poor Sleep Quality

Title
Firefighters Have Cerebral Blood Flow Reductions in the Orbitofrontal and Insular Cortices That are Associated with Poor Sleep Quality
Authors
Park, ShinwonHong, HaejinKim, Rye YoungMa, JiyoungLee, SujiHa, EunjiYoon, SujungKim, Jungyoon
Ewha Authors
윤수정김정윤이수지홍혜진하은지
SCOPUS Author ID
윤수정scopus; 김정윤scopus; 이수지scopus
Issue Date
2021
Journal Title
NATURE AND SCIENCE OF SLEEP
ISSN
1179-1608JCR Link
Citation
NATURE AND SCIENCE OF SLEEP vol. 13, pp. 1507 - 1517
Keywords
firefighterssleep efficiencywake after sleep onsetcerebral blood flowarterial spin labelingperfusion magnetic resonance imaging
Publisher
DOVE MEDICAL PRESS LTD
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
Purpose: To investigate the cerebral blood flow (CBF) alterations associated with poor sleep quality and memory performance in firefighters. Participants and Methods: Thirty-seven firefighters (the FF group) and 37 non-firefighter controls (the control group) with sleep complaints were enrolled in this study. We performed brain arterial spin labeling perfusion magnetic resonance imaging (MRI) and compared the CBF between the two groups using whole-brain voxel-wise analyses. Self-reported sleep problems and actigraphy-measured sleep parameters, including the sleep efficiency, wake after sleep onset (WASO), total sleep time, and sleep latency, were assessed. Spatial working memory and learning performances were evaluated on the day of the MRI scan. Results: The FF group, relative to the control group, had lower CBF in the right hemispheric regions: Middle temporal/lateral occipital, orbitofrontal, and insular cortices. Lower CBF in the right orbitofrontal cortex was linearly associated with poor sleep quality, as indicated by lower sleep efficiency and longer WASO. The CBF of the right insular cortex was also associated with longer WASO. Despite comparable degrees of self-reported sleep problems between the two groups, the FF group had lower sleep efficiency and longer WASO in the actigraphy, and lower spatial working memory and learning performance, relative to the control group. Poor sleep efficiency was linearly associated with lower spatial working memory performance. Conclusion: These results demonstrated an association of poor sleep quality with decreased brain perfusion in the right orbitofrontal and insular cortices, as well as with reduced working memory performance.
DOI
10.2147/NSS.S312671
Appears in Collections:
연구기관 > 뇌융합과학연구원 > Journal papers
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