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Antibacterial Bicyclic Fatty Acids from a Korean Colonial Tunicate Didemnum sp.

Title
Antibacterial Bicyclic Fatty Acids from a Korean Colonial Tunicate Didemnum sp.
Authors
Kim, HiyoungLee, Tae GuYang, InhoWang, WeihongChin, JungwookLee, JusungRho, Boon JoChoi, HyukjaeNam, Sang-JipHahn, DongyupKang, Heonjoong
Ewha Authors
노분조남상집
SCOPUS Author ID
노분조scopusscopus; 남상집scopusscopus
Issue Date
2021
Journal Title
MARINE DRUGS
ISSN
1660-3397JCR Link
Citation
MARINE DRUGS vol. 19, no. 9
Keywords
Didemnumantibacterialcolonial tunicatebicyclic fatty acids
Publisher
MDPI
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Five new bicyclic carboxylic acids were obtained by antibacterial activity-guided isolation from a Korean colonial tunicate Didemnum sp. Their structures were elucidated by the interpretation of NMR, MS and CD spectroscopic data. They all belong to the class of aplidic acids. Three of them were amide derivatives (1-3), and the other two were dicarboxylic derivatives (4 and 5). The absolute configurations were determined by a bisignate pattern of CD spectroscopy, which revealed that the absolute configurations of amides were opposite to those of dicarboxylates at every stereogenic centers. Compound 2 exhibited the most potent antibacterial activity (MIC, 2 mu g/mL).
DOI
10.3390/md19090521
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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