View : 122 Download: 0

Cinnamon(Cinnamomum japonicum) subcritical water extract suppresses gut damage induced by dextran sodium sulfate in mouse colitis model

Title
Cinnamon(Cinnamomum japonicum) subcritical water extract suppresses gut damage induced by dextran sodium sulfate in mouse colitis model
Authors
Kim M.S.Kim Y.D.Kang S.Kwon O.Shin J.-H.Kim J.Y.
Ewha Authors
권오란
SCOPUS Author ID
권오란scopusscopus
Issue Date
2021
Journal Title
Journal of Functional Foods
ISSN
1756-4646JCR Link
Citation
Journal of Functional Foods vol. 87
Keywords
Cinnamon(Cinnamomum japonicum)ColitisDextran sodium sulfateInflammationInflammatory bowel diseaseMicrobiome analysis
Publisher
Elsevier Ltd
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Inflammatory bowel disease involves the breaking down of tight junctions and triggers leaky gut syndrome. In this study, we evaluated the effect of cinnamon subcritical water extract (CSE) on gut health improvement using a mouse colitis model induced by 5 % dextran sodium sulfate. The mice were treated with varying concentrations of CSE for 21 days and assessed. We examined histopathological changes, mRNA expression of cytokines and tight junction proteins, and alteration of the gut microbiome. CSE treatment improved clinical symptoms. Moreover, myeloperoxidase activity, interleukin (IL)-1β, IL-6, tumor necrosis factor-α protein, and mRNA expression were reduced in the CSE-treated groups. However, CSE increased the mRNA expression of tight junction proteins, such as ZO-1, occludin, mucin-1, mucin-2, and E-cadherin. In addition, CSE altered the microbiome to reduce inflammation. These results suggested that CSE could prevent dextran sodium sulfate sodium-induced colitis and disruption of the intestinal environment. © 2021
DOI
10.1016/j.jff.2021.104775
Appears in Collections:
신산업융합대학 > 식품영양학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE